{"id":"W4389241392","doi":"10.1158/2326-6074.tumimm23-b007","title":"Abstract B007: Phenotypic Signatures of Circulating Neoantigen-Reactive CD8+ T Cells in Patients with Metastatic Cancers","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD8; T-cell receptor; Cytotoxic T cell; Immunotherapy; T cell; Biology; Antigen; Cancer immunotherapy; Immunology; Circulating tumor cell; Cancer research; Phenotype; Cancer; Immune system; Metastasis; Gene; In vitro; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008289081,0.0001311383,0.000170842,0.0002851325,0.000116192,0.0002148336,0.00007874089,0.0002464163,0.001587597],"category_scores_gemma":[0.000288708,0.00006610306,0.00007181033,0.0002022711,0.00009213584,0.0001046574,0.0001053758,0.0002483414,0.0003164176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009655987,"about_ca_system_score_gemma":0.00005489357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002475065,"about_ca_topic_score_gemma":0.0002269514,"domain_scores_codex":[0.999926,0.00001042889,0.000006086279,0.00002325956,0.00001800707,0.00001623107],"domain_scores_gemma":[0.9998749,0.00003440057,0.00002703149,0.000007849181,0.00002358954,0.00003217212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001700945,0.0001641921,0.4780719,0.00008724524,0.00002694884,0.0008741131,0.0003021184,0.0003390404,0.4953816,0.00005802421,0.0004429346,0.02255102],"study_design_scores_gemma":[0.00003919645,0.001392641,0.9519141,0.00001012439,0.00004145082,0.004599057,0.0002464231,0.001190533,0.03908954,0.00007845269,0.001391312,0.000007020509],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999209,0.00009898267,0.0001905321,0.00001337369,0.000001988021,0.000006300125,0.0001106286,0.000009848865,0.00035932],"genre_scores_gemma":[0.999323,0.00002995811,0.0002100334,0.00001604014,0.000004235802,0.000009542231,0.0002037594,0.000002887323,0.0002006507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001587597,"threshold_uncertainty_score":0.005311072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06538773514156315,"score_gpt":0.3875074509533458,"score_spread":0.3221197158117826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}