{"id":"W4389241392","doi":"10.1158/2326-6074.tumimm23-b007","title":"Abstract B007: Phenotypic Signatures of Circulating Neoantigen-Reactive CD8+ T Cells in Patients with Metastatic Cancers","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD8; T-cell receptor; Cytotoxic T cell; Immunotherapy; T cell; Biology; Antigen; Cancer immunotherapy; Immunology; Circulating tumor cell; Cancer research; Phenotype; Cancer; Immune system; Metastasis; Gene; In vitro; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001346297,0.0002241267,0.0006244648,0.001221152,0.000134247,0.00001967936,0.0003558771,0.0001769701,0.002470825],"category_scores_gemma":[0.0002440964,0.0001871677,0.00009157779,0.002509393,0.0008056306,0.0001194621,0.0001655377,0.001673547,0.00009615782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001072753,"about_ca_system_score_gemma":0.001510307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003624604,"about_ca_topic_score_gemma":0.0003620823,"domain_scores_codex":[0.9964207,0.0003406146,0.0004387291,0.0005578581,0.001110848,0.001131186],"domain_scores_gemma":[0.9975038,0.0008124789,0.0001309835,0.0006019711,0.0008250204,0.0001257801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006769878,0.0003054115,0.1341904,0.0003914831,0.001073052,0.0002098643,0.002423122,0.001485493,0.8208587,0.0000432337,0.0007216582,0.03152773],"study_design_scores_gemma":[0.006422059,0.0009675774,0.9199837,0.0004647813,0.00003498264,0.000002584747,0.001472061,0.0002293366,0.06934047,0.0001419456,0.0007222765,0.0002182119],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944211,0.001704081,0.000002899988,0.0002492805,0.0001765342,0.001396422,0.00004724852,0.00004846099,0.001953962],"genre_scores_gemma":[0.9973974,0.0005290724,0.0000496665,0.00003438404,0.00006005854,0.0002567028,0.0000604076,0.00007083912,0.001541442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7857933,"threshold_uncertainty_score":0.998441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06538773514156315,"score_gpt":0.3875074509533458,"score_spread":0.3221197158117826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}