{"id":"W4389241535","doi":"10.1158/2326-6074.tumimm23-a001","title":"Abstract A001: Reshaping the immune microenvironment after temozolomide priming in metastatic colorectal cancer patients in ARETHUSA clinical trial","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Temozolomide; Immune system; Immune checkpoint; Immunotherapy; MSH6; Medicine; DNA mismatch repair; Colorectal cancer; Cancer research; Oncology; Tumor microenvironment; Cancer; Immunology; Internal medicine; Biology; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009905886,0.0004337582,0.000968642,0.0002373335,0.0003408998,0.000594936,0.0002871389,0.0004693833,0.00376083],"category_scores_gemma":[0.0007350753,0.0001576551,0.0006763445,0.0002837232,0.0003575099,0.000389202,0.0002188192,0.001710865,0.0003691683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000329466,"about_ca_system_score_gemma":0.000762076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003733631,"about_ca_topic_score_gemma":0.001058478,"domain_scores_codex":[0.9997129,0.0001358912,0.00001490891,0.00003312915,0.00003369315,0.00006949471],"domain_scores_gemma":[0.9996575,0.00005927616,0.00008714179,0.00003022352,0.00003075509,0.0001351489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7736501,0.0154178,0.02125627,0.001062861,0.001429964,0.0003325738,0.0001908221,0.001062733,0.06425501,0.0004553769,0.007996956,0.1128895],"study_design_scores_gemma":[0.2850582,0.5306164,0.1522644,0.000143498,0.001563599,0.0005141764,0.0001787414,0.002175994,0.01313575,0.0003819942,0.01391745,0.00004975118],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950365,0.001191503,0.0001719736,0.00047776,0.00011183,0.0005686349,0.0006032108,0.00004417515,0.001794298],"genre_scores_gemma":[0.9949262,0.0006794814,0.0004365033,0.0004332251,0.0001382057,0.0007351252,0.00134864,0.00001225363,0.001290421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00376083,"threshold_uncertainty_score":0.01258129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08686040538991975,"score_gpt":0.4098916356056458,"score_spread":0.3230312302157261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}