{"id":"W4389241535","doi":"10.1158/2326-6074.tumimm23-a001","title":"Abstract A001: Reshaping the immune microenvironment after temozolomide priming in metastatic colorectal cancer patients in ARETHUSA clinical trial","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Temozolomide; Immune system; Immune checkpoint; Immunotherapy; MSH6; Medicine; DNA mismatch repair; Colorectal cancer; Cancer research; Oncology; Tumor microenvironment; Cancer; Immunology; Internal medicine; Biology; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002237257,0.0001914899,0.0003392588,0.0002227434,0.0001327188,0.00003988887,0.0005028559,0.0002379043,0.0001024779],"category_scores_gemma":[0.0006925325,0.0001639509,0.0001242181,0.0004285943,0.0006365807,0.000007664866,0.000624991,0.0008665262,0.00004400534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293786,"about_ca_system_score_gemma":0.0005196086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002554293,"about_ca_topic_score_gemma":0.006202913,"domain_scores_codex":[0.9970925,0.0004722043,0.0007418746,0.0006050117,0.0002539523,0.0008344993],"domain_scores_gemma":[0.998831,0.0004568244,0.0001286566,0.0004308955,0.00009185603,0.00006073139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07176846,0.001197898,0.524841,0.0001160254,0.0006536925,0.0001879356,0.001366048,0.001078658,0.319303,0.00003582607,0.004872125,0.0745794],"study_design_scores_gemma":[0.01582392,0.0006738888,0.9467981,0.0001040184,0.00001528345,0.000001289817,0.0003326319,0.00004689211,0.02424698,0.00007727244,0.01164315,0.0002366063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819066,0.01510296,0.000001101788,0.0009064813,0.0008355239,0.001080738,0.00008545891,0.000007227167,0.0000739128],"genre_scores_gemma":[0.9744833,0.02309781,0.00001551876,0.0001804188,0.000248293,0.001714325,0.00008906508,0.00003775187,0.0001335085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4219571,"threshold_uncertainty_score":0.6685722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08686040538991975,"score_gpt":0.4098916356056458,"score_spread":0.3230312302157261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}