{"id":"W4389241602","doi":"10.1158/2326-6074.tumimm23-pr06","title":"Abstract PR06: Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter prior to cell division","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tumor microenvironment; Immunology; T cell; CD8; Cytotoxic T cell; Epigenetics; Immunotherapy; Cancer; Biology; Cancer research; Cancer immunotherapy; Antigen; Context (archaeology); Medicine; Immune system; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001885649,0.0002132547,0.0005768607,0.0009354806,0.0001410664,0.00002288365,0.0003927676,0.0002326907,0.00084227],"category_scores_gemma":[0.0001864627,0.0001818788,0.0001663308,0.001631579,0.0004997553,0.0001365824,0.0002081961,0.0006778697,0.00008277427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003098311,"about_ca_system_score_gemma":0.0007533274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00169427,"about_ca_topic_score_gemma":0.0002021517,"domain_scores_codex":[0.9972349,0.0001756061,0.0006590304,0.0005112719,0.000747057,0.0006720688],"domain_scores_gemma":[0.9978104,0.000256349,0.0003063696,0.000710889,0.0008006546,0.0001153689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006783132,0.0002923694,0.05347638,0.0005241912,0.0001753174,0.0000478869,0.001424973,0.00004036167,0.9186228,0.000001876622,0.009808988,0.008801741],"study_design_scores_gemma":[0.002477811,0.0009843288,0.4840657,0.0006028419,0.00002039009,0.000005003308,0.002183478,0.00002247787,0.506865,0.00001229634,0.0026271,0.0001335296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917278,0.003733458,0.00001578371,0.0008846011,0.0007616387,0.0009867019,0.00007078368,0.00005943267,0.001759769],"genre_scores_gemma":[0.9950685,0.0018039,0.00007106803,0.0001123467,0.00009055431,0.000147736,0.00003869201,0.00005178537,0.002615447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4305893,"threshold_uncertainty_score":0.9222265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04536079984949287,"score_gpt":0.3556951633692391,"score_spread":0.3103343635197462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}