{"id":"W4389241602","doi":"10.1158/2326-6074.tumimm23-pr06","title":"Abstract PR06: Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter prior to cell division","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tumor microenvironment; Immunology; T cell; CD8; Cytotoxic T cell; Epigenetics; Immunotherapy; Cancer; Biology; Cancer research; Cancer immunotherapy; Antigen; Context (archaeology); Medicine; Immune system; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158526,0.0002382469,0.0002432303,0.0003777531,0.0002294557,0.0005845045,0.0001923764,0.0003904179,0.004926632],"category_scores_gemma":[0.0001716108,0.0001398653,0.0001548469,0.0002188547,0.0002999662,0.000346047,0.0003571804,0.0009002545,0.001736163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002436987,"about_ca_system_score_gemma":0.0001345166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003471934,"about_ca_topic_score_gemma":0.0004956392,"domain_scores_codex":[0.9998035,0.00001616875,0.00001398458,0.00006236687,0.00006612501,0.0000379123],"domain_scores_gemma":[0.9998248,0.00001843045,0.00005187165,0.00002498282,0.00003100865,0.00004900082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002488501,0.00002545915,0.00200918,0.00004029269,0.000003303586,0.0001569711,0.00005476154,0.00005734272,0.9920993,0.0002738838,0.000327194,0.004703524],"study_design_scores_gemma":[0.00001909632,0.0006250307,0.04977204,0.0000177993,0.00001243214,0.001276174,0.0001983395,0.0007735404,0.938128,0.0003000924,0.008865375,0.00001213452],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824087,0.001517183,0.007932816,0.0002306126,0.00008819094,0.00004693032,0.001814674,0.0004941437,0.005466845],"genre_scores_gemma":[0.9805531,0.0006666405,0.002867991,0.0001260924,0.00002909615,0.00006464034,0.001373312,0.0001051127,0.01421403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004926632,"threshold_uncertainty_score":0.01648122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04536079984949287,"score_gpt":0.3556951633692391,"score_spread":0.3103343635197462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}