{"id":"W4389241633","doi":"10.1158/1535-7163.targ-23-c082","title":"Abstract C082: SCD1 is a potent therapeutic target in MYC-amplified group 3 medulloblastoma","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University","funders":"","keywords":"Medulloblastoma; In vivo; Biology; Lipid metabolism; Cancer research; Wnt signaling pathway; Transcriptome; Enzyme; In vitro; Chemistry; Biochemistry; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006889782,0.0002480548,0.0002243036,0.0002279527,0.0001213278,0.0001914162,0.000138756,0.0002352112,0.001257782],"category_scores_gemma":[0.00005185095,0.00005477042,0.0001555123,0.0001743614,0.0001074805,0.00007654521,0.0001136444,0.0004796457,0.0003358223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630459,"about_ca_system_score_gemma":0.0002543714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009040418,"about_ca_topic_score_gemma":0.001859075,"domain_scores_codex":[0.9999635,0.000004415627,0.00000282265,0.000006851042,0.00001178678,0.00001049082],"domain_scores_gemma":[0.9999768,0.00000283542,0.000005200335,0.000001927084,0.000003566854,0.000009645736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007584781,0.0001125534,0.0005170822,0.00007485496,0.00001541729,0.00009330458,0.00001139757,0.0001794604,0.9888511,0.00009262202,0.0004276668,0.008866023],"study_design_scores_gemma":[0.000155431,0.001631377,0.006818091,0.00001062702,0.00004779046,0.0005246968,0.00002515689,0.0009261215,0.9805397,0.00006933962,0.009244997,0.000006733403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903063,0.004533117,0.001301213,0.0002352287,0.00007102687,0.00007672412,0.001345973,0.0001535057,0.001976808],"genre_scores_gemma":[0.9934874,0.001733714,0.001319986,0.0001224437,0.00001689378,0.00004123236,0.001390297,0.00001657335,0.00187133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257782,"threshold_uncertainty_score":0.004207671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090510750237412,"score_gpt":0.283688641232226,"score_spread":0.2627835337298519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}