{"id":"W4389241646","doi":"10.1158/1535-7163.targ-23-b169","title":"Abstract B169: Retrospective baseline biomarker analyses in a first-in-human Phase 1 trial of the PKMYT1 inhibitor lunresertib (RP-6306) in pts with advanced solid tumors harboring <i>CCNE1</i> amplification and/or deleterious alterations in <i>FBXW7</i> or <i>PPP2R1A</i>","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Internal medicine; Medicine; Oncology; Biomarker; Tolerability; Cyclin E1; Concordance; Fluorescence in situ hybridization; Cancer research; Cancer; Biology; Cyclin D1; Cell cycle; Adverse effect; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00170446,0.0005786527,0.001003656,0.0002739329,0.0005958499,0.00105315,0.0003827244,0.0005457298,0.002831949],"category_scores_gemma":[0.001573055,0.0003022,0.0005737325,0.0003858347,0.0004090557,0.0007214528,0.0004144056,0.001146791,0.0008754394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006849082,"about_ca_system_score_gemma":0.001024139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004877274,"about_ca_topic_score_gemma":0.0009794231,"domain_scores_codex":[0.9992148,0.0002407174,0.00006799368,0.0002331116,0.0001542056,0.00008913273],"domain_scores_gemma":[0.999029,0.0001751345,0.0002738035,0.0001322749,0.00009226352,0.0002974329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2476912,0.007299447,0.5545618,0.0008040607,0.002255847,0.002464404,0.0003652286,0.003568667,0.06296146,0.0008014738,0.01486268,0.1023637],"study_design_scores_gemma":[0.02045753,0.1182101,0.8043705,0.000130012,0.002339106,0.00534832,0.0002353529,0.004343965,0.01859459,0.001093286,0.02474862,0.0001286192],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861699,0.001858273,0.001213113,0.0002966826,0.00005492621,0.0006328257,0.006862981,0.00007736218,0.00283389],"genre_scores_gemma":[0.9831186,0.0003502999,0.001493761,0.0005154212,0.00007294428,0.0004427888,0.01299573,0.00003320806,0.0009773202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002831949,"threshold_uncertainty_score":0.009473741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03904351749104924,"score_gpt":0.35771871629522,"score_spread":0.3186751988041707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}