{"id":"W4389241744","doi":"10.1158/2326-6074.tumimm23-a043","title":"Abstract A043: Identifying critical vulnerabilities that sensitise <i>Lkb1</i>-mutant lung adenocarcinoma to T cell mediated killing","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"KRAS; Cancer research; Immune checkpoint; STK11; Biology; Adenocarcinoma; CD8; CRISPR; Immunotherapy; Cancer; Memory T cell; T cell; Immune system; Immunology; Gene; Genetics; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869937,0.0004024271,0.000327808,0.0003181536,0.0002392934,0.0003878895,0.0003388979,0.000536896,0.003756609],"category_scores_gemma":[0.0001479348,0.0001896829,0.0003956732,0.0001937986,0.0002334862,0.000146244,0.0002556949,0.0008497884,0.001192861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003946674,"about_ca_system_score_gemma":0.0003352798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009521192,"about_ca_topic_score_gemma":0.001182713,"domain_scores_codex":[0.9998085,0.00002418759,0.00002059863,0.00004318974,0.00005541528,0.00004809455],"domain_scores_gemma":[0.9998952,0.00001844293,0.00002791021,0.0000138576,0.00001684551,0.00002779268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001222546,0.0000343042,0.0002880512,0.00002919239,0.000007768035,0.00004569392,0.000006548763,0.0001382169,0.9977235,0.00006572172,0.0002201254,0.001318606],"study_design_scores_gemma":[0.00004477698,0.0009480106,0.004698548,0.000008031532,0.00004448067,0.000714678,0.00003503863,0.001802641,0.9855078,0.0000799972,0.006105359,0.00001053245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743988,0.001913508,0.01257328,0.0006235461,0.0001299678,0.0002493544,0.003901784,0.0005878514,0.005621935],"genre_scores_gemma":[0.9774731,0.001037596,0.01017864,0.0004620993,0.0000215717,0.0001648236,0.003521071,0.0001092573,0.007031898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003756609,"threshold_uncertainty_score":0.0125671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187534514791776,"score_gpt":0.4189211730398104,"score_spread":0.3001677215606328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}