{"id":"W4389241834","doi":"10.1158/2326-6074.tumimm23-b005","title":"Abstract B005: Molecular, metabolic and functional CD4 T cell paralysis in lymph node impedes tumor control","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"CD8; Biology; T cell; Lymph node; Adoptive cell transfer; Cancer research; Tumor-infiltrating lymphocytes; Epitope; Antigen; Immunology; Cell biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036199,0.0003236722,0.000153623,0.0001841698,0.0001374355,0.0002812605,0.000320734,0.0003467344,0.005674663],"category_scores_gemma":[0.00009316468,0.0001116009,0.0001600706,0.00008975248,0.0003033214,0.0001860964,0.0002069084,0.001075636,0.001119675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005210253,"about_ca_system_score_gemma":0.0003436265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008180365,"about_ca_topic_score_gemma":0.0006435795,"domain_scores_codex":[0.9998889,0.00001090775,0.000006806638,0.00002144885,0.00003399839,0.00003799126],"domain_scores_gemma":[0.9999261,0.00001167367,0.0000151482,0.000008179705,0.00001071359,0.00002819286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003845418,0.00006724746,0.0001740012,0.00005331383,0.000003144021,0.00003528511,0.00001420391,0.0001233589,0.9961336,0.0003990574,0.0001573216,0.002455085],"study_design_scores_gemma":[0.00005269516,0.0006259159,0.002344866,0.00001458268,0.00001098722,0.0001907223,0.00002925064,0.001887201,0.9898113,0.0001481541,0.004880948,0.000003431431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877664,0.001152167,0.003476763,0.0003430287,0.00007405425,0.00006462317,0.0005872478,0.0001855192,0.006350155],"genre_scores_gemma":[0.986283,0.0003317328,0.002247083,0.00008118033,0.00001682308,0.00005750281,0.0005535126,0.00003617476,0.01039291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005674663,"threshold_uncertainty_score":0.0189836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05391621309630305,"score_gpt":0.3794539962917979,"score_spread":0.3255377831954948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}