{"id":"W4389241863","doi":"10.1158/1535-7163.targ-23-c028","title":"Abstract C028: A phase 1/2 study investigating the safety and efficacy of autologous TAC T cells in subjects with unresectable, locally advanced or metastatic claudin 18.2+ solid tumors","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Chimeric antigen receptor; Radioimmunotherapy; Cancer research; Leukapheresis; Immunotherapy; Cancer; Monoclonal antibody; Immunology; Pharmacology; Antibody; Stem cell; Internal medicine; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001601406,0.00164453,0.001685028,0.0004701562,0.0006632876,0.0009513334,0.0009673273,0.001917033,0.004745844],"category_scores_gemma":[0.0007106382,0.0005535212,0.0009966271,0.0003387247,0.0009527885,0.0007146363,0.0002699047,0.003502125,0.001517845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009514917,"about_ca_system_score_gemma":0.002028903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001588303,"about_ca_topic_score_gemma":0.002739488,"domain_scores_codex":[0.9995722,0.0001601879,0.00001981486,0.0000870938,0.00005357737,0.0001070402],"domain_scores_gemma":[0.9991979,0.000100514,0.0001068983,0.0000691219,0.00008468249,0.0004408835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5034016,0.2361876,0.005808079,0.0009135888,0.0008072106,0.0007952483,0.0004636634,0.002020176,0.1653221,0.0003989454,0.01050457,0.07337738],"study_design_scores_gemma":[0.1608353,0.8252923,0.00457838,0.00001730392,0.0001748097,0.0002658112,0.0000548545,0.0007565547,0.005544276,0.0001014879,0.002358651,0.00002018981],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883568,0.0008613208,0.0007464091,0.00042202,0.0001561129,0.005293138,0.001922346,0.0001669896,0.002074863],"genre_scores_gemma":[0.9795681,0.0009567006,0.00216753,0.00134493,0.0002574556,0.006013691,0.003455522,0.00006562862,0.006170379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004745844,"threshold_uncertainty_score":0.01587641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05676514718190791,"score_gpt":0.3818371142617724,"score_spread":0.3250719670798645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}