{"id":"W4389241939","doi":"10.1158/1535-7163.targ-23-pr003","title":"Abstract PR003: Repotrectinib in patients with <i>ROS1</i> fusion-positive (<i>ROS1</i>+) non-small cell lung cancer (NSCLC): Update from the pivotal phase 1/2 TRIDENT-1 trial","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; University of Toronto","funders":"","keywords":"Medicine; Internal medicine; ROS1; Cohort; Clinical endpoint; Lung cancer; Oncology; Cancer; Clinical trial; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008401093,0.0005144827,0.0006393176,0.0001697759,0.0001470359,0.0006268621,0.0005198759,0.0004588512,0.006538398],"category_scores_gemma":[0.0005308365,0.0001145699,0.0008924838,0.0002707895,0.0002224734,0.0004382216,0.0002310793,0.001398065,0.0009042869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005952771,"about_ca_system_score_gemma":0.0005683123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00057662,"about_ca_topic_score_gemma":0.001877306,"domain_scores_codex":[0.9998139,0.00008159136,0.00001186841,0.00002705537,0.0000346328,0.00003088217],"domain_scores_gemma":[0.9997496,0.00004824615,0.0000813341,0.00001450058,0.00003570551,0.00007056975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3568021,0.005797239,0.01589323,0.004549926,0.003042233,0.0005634669,0.0001937305,0.001897894,0.07035629,0.0009681107,0.06956553,0.4703702],"study_design_scores_gemma":[0.5607756,0.2499006,0.09152028,0.0007488895,0.004382747,0.002737539,0.0002087406,0.003738639,0.02071871,0.001493972,0.06366131,0.000113021],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9387819,0.02887972,0.001553471,0.003548847,0.0004562488,0.001911653,0.008216796,0.0006335468,0.01601782],"genre_scores_gemma":[0.9681461,0.01014672,0.001586385,0.002395813,0.0003549083,0.001210005,0.01034438,0.00006659733,0.005749254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006538398,"threshold_uncertainty_score":0.02187312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375812211271293,"score_gpt":0.317288329426474,"score_spread":0.3035302073137611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}