{"id":"W4389242080","doi":"10.1158/1535-7163.targ-23-b035","title":"Abstract B035: A phase I/II trial investigating safety and efficacy of autologous TAC01-HER2 in relapsed or refractory solid tumors","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Cytokine release syndrome; Adverse effect; Chimeric antigen receptor; Pneumonitis; Internal medicine; T cell; Pharmacokinetics; Leukapheresis; Immunotherapy; Refractory (planetary science); Oncology; Gastroenterology; Pharmacology; Cancer; Immunology; Immune system; Lung; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001689181,0.00114184,0.001328048,0.0003878252,0.0004325552,0.0008860518,0.0008974107,0.001109592,0.006643045],"category_scores_gemma":[0.0006468879,0.0004063727,0.0008562788,0.0003814408,0.0007764195,0.0005865576,0.000298163,0.002713421,0.00171696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008861004,"about_ca_system_score_gemma":0.00177536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001572663,"about_ca_topic_score_gemma":0.002617477,"domain_scores_codex":[0.9995906,0.0002068118,0.00002233949,0.00006082327,0.00004108908,0.00007835063],"domain_scores_gemma":[0.9994228,0.00008569917,0.00008238104,0.00004533497,0.000030364,0.0003335538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7379289,0.07720813,0.006539445,0.0008637152,0.00129984,0.000523282,0.0002230676,0.001844501,0.05884608,0.0005603977,0.01147955,0.1026831],"study_design_scores_gemma":[0.5823302,0.4012415,0.006750006,0.00004687752,0.0002982868,0.0003035336,0.00005368484,0.001601993,0.004345085,0.0002487716,0.002759557,0.0000205475],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869907,0.001781676,0.000650166,0.0007321367,0.0001520903,0.002930378,0.002890823,0.0001784016,0.003693658],"genre_scores_gemma":[0.9827387,0.001274108,0.001849683,0.00167444,0.000166722,0.002583923,0.00553024,0.00004810753,0.004133987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006643045,"threshold_uncertainty_score":0.02222323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07208883215688347,"score_gpt":0.3961923356484441,"score_spread":0.3241035034915606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}