{"id":"W4389242918","doi":"10.1182/blood-2023-179387","title":"Durable Efficacy and Manageable Safety in Patients Age ≥ 75 Years with Relapsed/Refractory Large B-Cell Lymphoma Treated with Tisagenlecleucel in the Real-World Setting","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Cytokine release syndrome; Internal medicine; Oncology; Blinatumomab; Clinical trial; Salvage therapy; Refractory (planetary science); Chimeric antigen receptor; CD19; Immunotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006338167,0.0001207646,0.0002623974,0.000313254,0.0002357376,0.0006368925,0.000162567,0.0001283137,0.0006971296],"category_scores_gemma":[0.001066549,0.00005898149,0.0003054669,0.0003794592,0.000172993,0.0002771259,0.0002629792,0.000289269,0.0001309319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006857589,"about_ca_system_score_gemma":0.0004736423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002172879,"about_ca_topic_score_gemma":0.004279946,"domain_scores_codex":[0.9997503,0.00006679668,0.00002606741,0.00004273536,0.00004673399,0.00006734138],"domain_scores_gemma":[0.9993279,0.00008687503,0.0003967331,0.00002102514,0.00003745078,0.0001301729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006184051,0.0006783834,0.966549,0.00005923989,0.0002221755,0.0003449919,0.0001669055,0.0004378989,0.001467214,0.00003855798,0.0005949679,0.02325658],"study_design_scores_gemma":[0.0004647233,0.004278623,0.9915906,0.00001561052,0.0001586326,0.0007198816,0.000182785,0.000552015,0.0005592341,0.00003914053,0.001429097,0.000009755652],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991344,0.0002121771,0.00004869252,0.00002926647,0.000002613405,0.00001532241,0.0002147634,0.000003697518,0.0003390551],"genre_scores_gemma":[0.9993733,0.0000807593,0.00004437483,0.00004289331,0.000007969152,0.00001361319,0.0003806111,8.49657e-7,0.00005577004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002172879,"threshold_uncertainty_score":0.004975617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183404304866998,"score_gpt":0.2521407502571448,"score_spread":0.2403067072084749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}