{"id":"W4389242944","doi":"10.1182/blood-2023-180920","title":"Bellwave-010: Phase 3, Open-Label, Randomized Study of Nemtabrutinib Plus Venetoclax Versus Venetoclax Plus Rituximab in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Following at Least One Prior Therapy","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Venetoclax; Ibrutinib; Chronic lymphocytic leukemia; Tumor lysis syndrome; Rituximab; Medicine; Bruton's tyrosine kinase; Internal medicine; Oncology; Neutropenia; Lymphoma; Gastroenterology; Immunology; Leukemia; Chemotherapy; Tyrosine kinase; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002304631,0.00201169,0.002050559,0.0004606505,0.000540635,0.001645611,0.001535665,0.002271483,0.01120965],"category_scores_gemma":[0.001382548,0.0007824837,0.001991505,0.0004509902,0.001379313,0.001638378,0.0004782608,0.005704079,0.002183553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001491066,"about_ca_system_score_gemma":0.001973846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001564077,"about_ca_topic_score_gemma":0.004955702,"domain_scores_codex":[0.9994128,0.0002856117,0.00002261601,0.00009931436,0.00005185823,0.0001278719],"domain_scores_gemma":[0.9990699,0.0001792912,0.0002155971,0.00004997528,0.00006460439,0.0004207259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9466227,0.02211942,0.000958251,0.0007228801,0.000846151,0.00006183216,0.00007736164,0.0004570706,0.004809692,0.0002302926,0.003860097,0.01923422],"study_design_scores_gemma":[0.90656,0.08957069,0.001641957,0.00003200983,0.0002269957,0.00005709624,0.00002453328,0.0004550583,0.0002748519,0.0001397364,0.0009998684,0.00001730094],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740181,0.006026765,0.001016988,0.001755935,0.0007475326,0.006935372,0.003707811,0.0004545704,0.005336965],"genre_scores_gemma":[0.9613824,0.004340144,0.003591605,0.006190376,0.0007032921,0.009369037,0.005776752,0.0001010319,0.0085452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01120965,"threshold_uncertainty_score":0.03749996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05429168065775831,"score_gpt":0.3259056005492849,"score_spread":0.2716139198915266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}