{"id":"W4389243001","doi":"10.1182/blood-2023-190720","title":"Multiple Myeloma B Cells and Pre-Plasma Cells Are Important Reservoirs for Myeloma Relapse Following Plasma Cell-Directed Therapy and Prevent Cure with Standard Therapies","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Pomalidomide; Daratumumab; Carfilzomib; Lenalidomide; Bortezomib; Plasma cell; Multiple myeloma; Plasma Cell Myeloma; CD20; Cancer research; clone (Java method); Plasma cell neoplasm; Plasma cell leukemia; CD38; Medicine; Biology; Stem cell; Immunology; Lymphoma; CD34; Plasmacytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003181369,0.0002114857,0.0003741029,0.0004629978,0.0002827419,0.0006061043,0.0002314498,0.0003385717,0.001693179],"category_scores_gemma":[0.0004652073,0.0001703113,0.0002302502,0.0004504214,0.0002105516,0.0003853597,0.0003815252,0.0006620134,0.0005623614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003469389,"about_ca_system_score_gemma":0.0002011015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009188238,"about_ca_topic_score_gemma":0.001311062,"domain_scores_codex":[0.9997362,0.00003316141,0.00001215424,0.00008266332,0.00009647101,0.00003933165],"domain_scores_gemma":[0.9998131,0.00003395631,0.00006683682,0.00001832333,0.00004216213,0.00002560831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001041607,0.00009821774,0.1342202,0.0004048201,0.0001847618,0.0009056163,0.0007175379,0.00161685,0.7378126,0.001165597,0.002423443,0.1194086],"study_design_scores_gemma":[0.00004507788,0.0006894508,0.7641019,0.0001527279,0.0002530036,0.004818672,0.0008280072,0.006809102,0.1737249,0.003184482,0.04534792,0.00004480166],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713747,0.009893847,0.01244671,0.0005672573,0.00004458679,0.00006456817,0.001658746,0.0003482951,0.003601279],"genre_scores_gemma":[0.9896898,0.002225886,0.004278459,0.0004925759,0.00003386152,0.0000760389,0.001345707,0.00006474247,0.001792962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001693179,"threshold_uncertainty_score":0.005664289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01934977455210896,"score_gpt":0.2675097893738075,"score_spread":0.2481600148216985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}