{"id":"W4389243100","doi":"10.1182/blood-2023-189475","title":"Generation and Screening of Various CD70 CAR NK Cells Identify the Most Effective Construct Against Hematologic Malignancies","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chimeric antigen receptor; Cancer research; Biology; Immunology; Cytotoxic T cell; Immunotherapy; Natural killer T cell; CD28; Immune system; Antigen; Cancer; Lymphokine-activated killer cell; Interleukin 21; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398471,0.0004247672,0.0004546887,0.0004920768,0.0001955139,0.0003961985,0.0003370601,0.000320181,0.001511848],"category_scores_gemma":[0.0002299108,0.0001438734,0.0002970335,0.0003837686,0.0001630834,0.0002006356,0.0003090845,0.0006289045,0.0004383702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003351111,"about_ca_system_score_gemma":0.000252623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004343114,"about_ca_topic_score_gemma":0.0007350388,"domain_scores_codex":[0.9997492,0.00003761436,0.00003146366,0.00004743555,0.00006416511,0.00007008868],"domain_scores_gemma":[0.9999168,0.00001588844,0.00001062604,0.00001113063,0.00002209429,0.00002351779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002618727,0.00042647,0.0007688226,0.0001893182,0.00002165626,0.0001108583,0.0000846785,0.001247013,0.9808782,0.0004811623,0.0004692845,0.01506058],"study_design_scores_gemma":[0.0001052734,0.002491122,0.002358551,0.00002564339,0.0001155761,0.0004507025,0.00008941505,0.002207824,0.9780602,0.0001173757,0.01396348,0.00001493204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812124,0.003351239,0.01047413,0.000185005,0.00004997167,0.0007475344,0.001103513,0.0001523641,0.002723767],"genre_scores_gemma":[0.9790717,0.002385758,0.01235712,0.0001169225,0.00002232892,0.000497416,0.002480284,0.0000421695,0.003026323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511848,"threshold_uncertainty_score":0.005057633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525632252369961,"score_gpt":0.2341702670163428,"score_spread":0.2189139444926432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}