{"id":"W4389243140","doi":"10.1182/blood-2023-190168","title":"Efficacy and Tolerance of Isatuximab, Cyclophosphamide, Bortezomib, and Dexamethasone (Isa-CBD) Induction Chemotherapy in Newly Diagnosed, Transplant Eligible Multiple Myeloma: Report of the Phase 2 Multi-Centre, Open Label Canadian Myeloma Research Group (CMRG)-008 Prospective Clinical Trial","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Ottawa Hospital; Princess Margaret Cancer Centre; Dalhousie University; University of Saskatchewan; Queen Elizabeth II Health Sciences Centre; CancerCare Manitoba","funders":"","keywords":"Lenalidomide; Medicine; Melphalan; Multiple myeloma; Internal medicine; Autologous stem-cell transplantation; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006555282,0.001590967,0.002023596,0.0004601995,0.0007070006,0.001535685,0.00145666,0.001530722,0.001634487],"category_scores_gemma":[0.002699097,0.000843025,0.001486198,0.0007415257,0.001960566,0.0009661461,0.0005628025,0.003758743,0.0004280125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002398523,"about_ca_system_score_gemma":0.003752669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004644275,"about_ca_topic_score_gemma":0.009282281,"domain_scores_codex":[0.9982924,0.0009442919,0.0001159335,0.0002126891,0.0001759801,0.0002587149],"domain_scores_gemma":[0.9964706,0.0007189504,0.0009239715,0.0003227757,0.0001931111,0.001370614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8762794,0.05532105,0.01964365,0.0003743849,0.001121803,0.0001677117,0.0004140965,0.001287259,0.01060234,0.00008642995,0.001355983,0.03334602],"study_design_scores_gemma":[0.4374223,0.5227619,0.03409484,0.00003677632,0.0008011645,0.0002721972,0.00007880117,0.0006605017,0.002538091,0.00009945472,0.001186419,0.000047572],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967173,0.001018574,0.0001504837,0.0001431928,0.00003871858,0.001005285,0.0003823432,0.00002139187,0.0005228307],"genre_scores_gemma":[0.995097,0.000800562,0.0007050686,0.0004137369,0.0001385606,0.0009857606,0.001148639,0.00001282013,0.0006978419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006555282,"threshold_uncertainty_score":0.03466803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1226549250003856,"score_gpt":0.4250328955985352,"score_spread":0.3023779705981496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}