{"id":"W4389243194","doi":"10.1182/blood-2023-190230","title":"<i>BTG2</i> Super-Enhancer Mutations Disrupt TFAP4 Binding and Deregulate BTG2 Expression in Diffuse Large B-Cell Lymphoma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Biology; Diffuse large B-cell lymphoma; Somatic hypermutation; Cancer research; Genetics; Enhancer; Gene; Lymphoma; B cell; Transcription factor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006702612,0.000150129,0.0001248477,0.0001517629,0.00007782701,0.0001357562,0.0001036355,0.0001114713,0.001335174],"category_scores_gemma":[0.00006817401,0.00008104697,0.0001371552,0.000126585,0.0001563046,0.0000616733,0.0001124994,0.0002758174,0.0003397002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056994,"about_ca_system_score_gemma":0.0001052638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059092,"about_ca_topic_score_gemma":0.002119608,"domain_scores_codex":[0.9999353,0.000008982704,0.000005417591,0.00001350436,0.0000216307,0.00001532902],"domain_scores_gemma":[0.9999671,0.000006593032,0.000009541836,0.000003763674,0.00000208152,0.00001099026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005503902,0.00001622234,0.0009351303,0.00001260641,0.000005013269,0.00009727827,0.000008902174,0.00007488941,0.9972613,0.00004564353,0.00005337715,0.001434605],"study_design_scores_gemma":[0.00002709469,0.0002435914,0.04270616,0.000006064583,0.0000261339,0.002880475,0.00005439599,0.001786203,0.9488758,0.00009548286,0.003293281,0.00000530706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975332,0.000323861,0.0009139681,0.00005137887,0.000008360393,0.00001121097,0.0003282268,0.00007039684,0.0007594032],"genre_scores_gemma":[0.9985421,0.0001511919,0.0003783857,0.00003836381,0.000002228166,0.000006820522,0.0002781932,0.00001365899,0.0005891063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335174,"threshold_uncertainty_score":0.004466593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005929685323243366,"score_gpt":0.2326254506934015,"score_spread":0.2266957653701581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}