{"id":"W4389243209","doi":"10.1182/blood-2023-186969","title":"Gene Expression Profiling Reveals Two Overarching Types of Anaplastic Large Cell Lymphoma with Distinct Targetable Biology: An L.L.M.P.P. Study","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Toronto; Spinal Cord Injury BC","funders":"","keywords":"Anaplastic large-cell lymphoma; Biology; Gene expression profiling; Cancer research; Subtyping; Fluorescence in situ hybridization; Lymphoma; Genetics; Gene; Gene expression; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004780001,0.000187502,0.0002525272,0.0006527017,0.0002883254,0.0006174878,0.0002213227,0.0004296143,0.001263381],"category_scores_gemma":[0.0004388796,0.0001297149,0.000315891,0.0005397764,0.0004072009,0.0002447218,0.0003639082,0.0004026499,0.0004411951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264523,"about_ca_system_score_gemma":0.0001945414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004017697,"about_ca_topic_score_gemma":0.0005552422,"domain_scores_codex":[0.9997049,0.00005450602,0.0000172235,0.0001119215,0.00006050934,0.00005087764],"domain_scores_gemma":[0.9997292,0.00008615211,0.00004117528,0.00003638619,0.00005705603,0.00004998928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002707354,0.0007019415,0.6062948,0.0001478488,0.0002214172,0.004368945,0.0007968145,0.0003073368,0.3322465,0.0004556891,0.001176192,0.05057512],"study_design_scores_gemma":[0.00009471588,0.001599449,0.9525371,0.00002425549,0.0002105729,0.01346197,0.0008933794,0.001821941,0.02402846,0.0004595179,0.004846601,0.00002212948],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976829,0.0003898416,0.0007860475,0.00008785076,0.000003227452,0.00001699612,0.0002270394,0.00001409076,0.0007919833],"genre_scores_gemma":[0.9982166,0.0001922069,0.0006130673,0.0001157426,0.00001460242,0.00003819038,0.0004031776,0.000008134918,0.0003982994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263381,"threshold_uncertainty_score":0.004226446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161638350444922,"score_gpt":0.2848491811892356,"score_spread":0.2686853461447434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}