{"id":"W4389243379","doi":"10.1182/blood-2023-187663","title":"CAR T Cell Exhaustion but Not <i>Ex Vivo</i> Cytotoxicity Is Predictive of Patient Clinical Response: An Interim Analysis of ACIT001/EXC002, a Phase Ib/II Trial of Decentralized Production of CAR T Cells for Treatment of Relapsed/Refractory Aggressive NHL and ALL","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"","keywords":"Chimeric antigen receptor; Medicine; Immunophenotyping; Ex vivo; Immunotherapy; Oncology; Immunology; Lymphoma; Internal medicine; Cytotoxic T cell; T cell; Antigen; Immune system; In vivo; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002592166,0.0005283064,0.0009597689,0.0002503622,0.0002810599,0.0008858948,0.000574609,0.0006453167,0.0008219567],"category_scores_gemma":[0.001506098,0.0002211254,0.0005778777,0.0003154171,0.0005336834,0.0003682883,0.0002260131,0.001509519,0.0002137251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001285241,"about_ca_system_score_gemma":0.001897339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003348742,"about_ca_topic_score_gemma":0.007203674,"domain_scores_codex":[0.9992805,0.0001873577,0.00003304138,0.0001203426,0.0002050261,0.0001737868],"domain_scores_gemma":[0.9986986,0.0003299804,0.0002574413,0.0001625481,0.0001550492,0.0003964825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3490742,0.01394951,0.2496452,0.0004397102,0.001071076,0.0008149532,0.0005693731,0.01185071,0.2092746,0.0005409766,0.005118196,0.1576516],"study_design_scores_gemma":[0.02157104,0.3018807,0.5876551,0.0000458529,0.001637122,0.001408581,0.0002254057,0.01547525,0.06050447,0.0004314016,0.00905005,0.0001148123],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970867,0.0004606757,0.0004410018,0.00008803261,0.000009978631,0.0002259617,0.0006516117,0.00002370896,0.001012375],"genre_scores_gemma":[0.9956304,0.000120845,0.0004615154,0.0002731433,0.00002070267,0.0001604305,0.002534613,0.000009881078,0.0007886132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003348742,"threshold_uncertainty_score":0.01370883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0644916410500575,"score_gpt":0.3929571026369683,"score_spread":0.3284654615869108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}