{"id":"W4389243387","doi":"10.1182/blood-2023-180789","title":"Treatment Patterns and Modifications of Tyrosine Kinase Inhibitors (TKI) Therapy in Early Lines in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP): Real-World Analysis from a Large Commercial Claims Database in the United States (US)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Group for Research in Decision Analysis","funders":"","keywords":"Medicine; Bosutinib; Dasatinib; Nilotinib; Discontinuation; Internal medicine; Ponatinib; Imatinib mesylate; Oncology; Tolerability; Imatinib; Myeloid leukemia; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001581526,0.0002572724,0.0003952137,0.001635853,0.0003285968,0.001072336,0.0005778945,0.0005351063,0.00123541],"category_scores_gemma":[0.004871565,0.0002472869,0.000640671,0.003688493,0.0002967344,0.0007744008,0.0006538707,0.0006274491,0.0002413356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008303223,"about_ca_system_score_gemma":0.0007362043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008316739,"about_ca_topic_score_gemma":0.01261275,"domain_scores_codex":[0.997915,0.0004258588,0.0005589057,0.0005046331,0.0004346405,0.0001609448],"domain_scores_gemma":[0.9874878,0.001391385,0.009686585,0.0003960002,0.0004880939,0.0005501931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001420049,0.00003320873,0.9987854,0.00001793417,0.00006528416,0.00003113664,0.00002588541,0.00005042393,0.00005203755,0.00001196806,0.0001882293,0.000596537],"study_design_scores_gemma":[0.00002580989,0.00007561866,0.9984864,0.00001613376,0.00004576428,0.0002600474,0.0001379144,0.0004497057,0.00007138419,0.00001557039,0.0004092253,0.000006306421],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924993,0.0003063671,0.00007750968,0.00007781453,0.000003630206,0.00003777355,0.006726424,0.000005333682,0.0002658052],"genre_scores_gemma":[0.9920865,0.0001740105,0.0001922692,0.00007154914,0.00001153365,0.00004595187,0.007332644,0.000002843173,0.00008262073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008316739,"threshold_uncertainty_score":0.01653665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283391076953097,"score_gpt":0.2936828101174232,"score_spread":0.2708488993478922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}