{"id":"W4389243476","doi":"10.1182/blood-2023-178112","title":"Use of Geriatric Assessment and Genetic Profiling to Personalize Selection of Intensive Versus Low Intensity Chemotherapy in Older Adults with Acute Myeloid Leukemia (AML): Final Results of a Phase II Trial","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Internal medicine; Oncology; Chemotherapy regimen; Performance status; Chemotherapy; Intensive care medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006194948,0.001188842,0.001877628,0.0002850004,0.0004007041,0.001429609,0.0005919805,0.001477249,0.00272518],"category_scores_gemma":[0.005697181,0.0003567871,0.002672128,0.0003627026,0.0006500432,0.001287375,0.0006456985,0.003358721,0.0005297703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008470897,"about_ca_system_score_gemma":0.001268547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004932278,"about_ca_topic_score_gemma":0.001447422,"domain_scores_codex":[0.9980744,0.001318032,0.0001338472,0.0001812134,0.0001482561,0.0001441951],"domain_scores_gemma":[0.9974691,0.0008574043,0.0004648096,0.00025845,0.0002757871,0.0006745677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.850009,0.02099737,0.008523216,0.001313086,0.004931509,0.00004766244,0.0002195804,0.001240356,0.00267719,0.0003836848,0.00428634,0.105371],"study_design_scores_gemma":[0.8038589,0.1718509,0.01444434,0.0003308256,0.003081704,0.00005799743,0.00006306822,0.001258906,0.0005649911,0.0008476949,0.00359324,0.00004744092],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597782,0.01267718,0.002264065,0.006135073,0.0008944958,0.01083666,0.002404731,0.0001239919,0.004885573],"genre_scores_gemma":[0.9624579,0.005187096,0.007157667,0.004746851,0.0009847839,0.01527507,0.002147655,0.00003320226,0.002009758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006194948,"threshold_uncertainty_score":0.03276241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03449539942742545,"score_gpt":0.3306603888898472,"score_spread":0.2961649894624218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}