{"id":"W4389243538","doi":"10.1182/blood-2023-189863","title":"Danicopan As Add-on Therapy to Ravulizumab or Eculizumab Versus Placebo in Patients with Paroxysmal Nocturnal Hemoglobinuria and Clinically Significant Extravascular Hemolysis: Phase 3 Long-Term Data","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Eculizumab; Population; Placebo; Internal medicine; Gastroenterology; Hemoglobinuria; Hemolysis; Double blind; Surgery; Immunology; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002753965,0.001386801,0.002773855,0.0005540018,0.0004227026,0.00106017,0.001153258,0.001506058,0.00385104],"category_scores_gemma":[0.002061963,0.0004172384,0.002747664,0.0004385307,0.001086308,0.00111785,0.0003369016,0.002615404,0.0005717163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008191125,"about_ca_system_score_gemma":0.001177691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203564,"about_ca_topic_score_gemma":0.003098377,"domain_scores_codex":[0.9991301,0.0004948861,0.00007212114,0.0001100438,0.00006307505,0.0001296907],"domain_scores_gemma":[0.998425,0.0005440707,0.0003366987,0.0001056373,0.0001059729,0.0004826831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9346854,0.009009,0.001220142,0.001708106,0.002589442,0.0001038941,0.0000836738,0.0007033309,0.005762708,0.0001073449,0.002000388,0.04202655],"study_design_scores_gemma":[0.7494638,0.2335617,0.009033846,0.0002296911,0.002680569,0.0001842479,0.0000626272,0.0008091602,0.001526824,0.0002615269,0.002136543,0.00004955675],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571628,0.03164177,0.0008915897,0.001252972,0.0005036377,0.002067854,0.002579367,0.0001674655,0.003732572],"genre_scores_gemma":[0.9806508,0.01064363,0.001176297,0.001675686,0.0004858706,0.001749721,0.001864975,0.0000290051,0.001724024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00385104,"threshold_uncertainty_score":0.01456451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05198281000273264,"score_gpt":0.3343954299850811,"score_spread":0.2824126199823485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}