{"id":"W4389243549","doi":"10.1182/blood-2023-180926","title":"Safety and Preliminary Efficacy of Sabestomig (AZD7789), an Anti-PD-1 and Anti-TIM-3 Bispecific Antibody, in Patients with Relapsed or Refractory Classical Hodgkin Lymphoma Previously Treated with Anti-PD-(L)1 Therapy","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Jewish General Hospital","funders":"","keywords":"Medicine; Refractory (planetary science); Antibody; Radioimmunotherapy; Lymphoma; Classical Hodgkin lymphoma; Monoclonal antibody; Internal medicine; Cancer research; Oncology; Immunology; Biology; Hodgkin lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009677357,0.0006491072,0.001367397,0.0003474642,0.0002938319,0.0005362634,0.0003733285,0.0006599214,0.0008353469],"category_scores_gemma":[0.001074071,0.000175394,0.0008634301,0.0002687807,0.0005831378,0.0005103579,0.0002811015,0.001388901,0.0002911818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006136596,"about_ca_system_score_gemma":0.0005917027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006057168,"about_ca_topic_score_gemma":0.0008866455,"domain_scores_codex":[0.999561,0.0002181735,0.00003658088,0.00006076709,0.000047904,0.00007551387],"domain_scores_gemma":[0.9992041,0.0002235616,0.0001656133,0.0000758684,0.00004983164,0.0002811039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3952371,0.03043851,0.06386217,0.0008478467,0.001644659,0.00140686,0.0005639241,0.007111507,0.1575835,0.0003135653,0.002202597,0.3387878],"study_design_scores_gemma":[0.06345806,0.7674905,0.1247936,0.00004615597,0.0009681243,0.001635905,0.0001147394,0.005215633,0.03126119,0.0003179191,0.004652714,0.00004549017],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996139,0.001710678,0.0004288701,0.0001364277,0.00003354738,0.0002255628,0.000366777,0.0000507962,0.0009083567],"genre_scores_gemma":[0.9978026,0.0005197073,0.0003126638,0.0001868287,0.00007509344,0.0001537509,0.0005856337,0.000006752869,0.0003570408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367397,"threshold_uncertainty_score":0.005117953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431239092951215,"score_gpt":0.2590484232701427,"score_spread":0.2447360323406306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}