{"id":"W4389243603","doi":"10.1182/blood-2023-179304","title":"Efficacy and Safety of Valemetostat Monotherapy in Patients with Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results of the Phase 2 VALENTINE-PTCL01 Study","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Brentuximab vedotin; Peripheral T-cell lymphoma; Anaplastic large-cell lymphoma; Lymphoma; Oncology; Neutropenia; Phases of clinical research; Progression-free survival; Surrogate endpoint; Refractory (planetary science); Gastroenterology; Clinical trial; Chemotherapy; Immunology; Hodgkin lymphoma; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002252144,0.001103299,0.001800628,0.0002994938,0.0002603321,0.0008447075,0.0005927724,0.001000455,0.002018072],"category_scores_gemma":[0.001215076,0.0004372988,0.001491774,0.0003165241,0.0004606999,0.0008398864,0.0003133711,0.001749977,0.0005491352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007834723,"about_ca_system_score_gemma":0.0007727558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004500787,"about_ca_topic_score_gemma":0.001285119,"domain_scores_codex":[0.9992718,0.0004152279,0.00004810615,0.0001188204,0.00007053286,0.00007551938],"domain_scores_gemma":[0.999124,0.0001957242,0.0002702156,0.00008546937,0.0000870604,0.0002374751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7903115,0.02251673,0.02834797,0.001610311,0.00548368,0.0002750729,0.0003289739,0.001995303,0.0299694,0.0001138487,0.004013186,0.1150341],"study_design_scores_gemma":[0.4610048,0.4315637,0.09206799,0.0001037481,0.003508073,0.0007087734,0.0001099778,0.001450634,0.004843361,0.000211894,0.004362758,0.00006413273],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933801,0.002938882,0.0002328434,0.0001663019,0.0000436455,0.000881002,0.001261413,0.0000532602,0.001042513],"genre_scores_gemma":[0.9936703,0.001306083,0.0004697129,0.0004323314,0.0001132827,0.0007893975,0.002311125,0.00001962244,0.0008880526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002252144,"threshold_uncertainty_score":0.01191062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009085163304936425,"score_gpt":0.2265714869823555,"score_spread":0.2174863236774191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}