{"id":"W4389243603","doi":"10.1182/blood-2023-179304","title":"Efficacy and Safety of Valemetostat Monotherapy in Patients with Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results of the Phase 2 VALENTINE-PTCL01 Study","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Brentuximab vedotin; Peripheral T-cell lymphoma; Anaplastic large-cell lymphoma; Lymphoma; Oncology; Neutropenia; Phases of clinical research; Progression-free survival; Surrogate endpoint; Refractory (planetary science); Gastroenterology; Clinical trial; Chemotherapy; Immunology; Hodgkin lymphoma; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002345512,0.0001707678,0.0003825432,0.00009521495,0.0001136987,0.000002956355,0.0001666274,0.00009408879,0.00002245182],"category_scores_gemma":[0.00005044317,0.00009298296,0.00004906761,0.0003201274,0.0002339342,0.00003774182,0.000119606,0.0001445638,0.000004266458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001679965,"about_ca_system_score_gemma":0.00006295725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008805846,"about_ca_topic_score_gemma":0.00005679372,"domain_scores_codex":[0.9987247,0.0002450729,0.0004502965,0.0002738003,0.0000754962,0.0002306576],"domain_scores_gemma":[0.9991559,0.0001928721,0.0002601743,0.0003197539,0.00005907617,0.00001225748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04028643,0.0193566,0.7548754,0.0001353258,0.0009018478,0.00001182529,0.01091757,0.000007380092,0.1680731,0.000003448801,0.0005183602,0.00491269],"study_design_scores_gemma":[0.1453611,0.004310043,0.8299667,0.00007289829,0.0001456784,0.000001430062,0.0009748081,2.743481e-7,0.01741782,0.000002304314,0.001596072,0.0001508662],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976132,0.0008975537,4.291682e-7,0.0000260864,0.0001461046,0.0007528532,0.000147635,0.00002799633,0.0003881723],"genre_scores_gemma":[0.9975713,0.0003392082,0.00001677833,0.00001887511,0.000007823432,0.00001399792,0.00004553064,0.00001864831,0.001967869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1506553,"threshold_uncertainty_score":0.3791735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009085163304936425,"score_gpt":0.2265714869823555,"score_spread":0.2174863236774191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}