{"id":"W4389243745","doi":"10.1182/blood-2023-182434","title":"A Phase 1 Study Evaluating PRT2527, a Potent and Highly Selective CDK9 Inhibitor, As Monotherapy and in Combination with Zanubrutinib in Patients with Select Relapsed/Refractory B-Cell Malignancies","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Tolerability; Ibrutinib; Cancer research; Combination therapy; Medicine; Pharmacology; Internal medicine; Adverse effect; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001086803,0.001377128,0.001576828,0.0005248837,0.0004440393,0.0009878875,0.000914917,0.0009548631,0.003831786],"category_scores_gemma":[0.000555651,0.0005558779,0.001296081,0.0004224535,0.0008001819,0.0008027457,0.0002614387,0.002615354,0.0009694383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00110313,"about_ca_system_score_gemma":0.001584601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001369882,"about_ca_topic_score_gemma":0.004171286,"domain_scores_codex":[0.9997051,0.0001053349,0.00001283303,0.0000736185,0.00003108873,0.00007190551],"domain_scores_gemma":[0.9995832,0.00004770788,0.00006833657,0.00003096262,0.00003038664,0.0002395059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5094708,0.1191501,0.008792247,0.001788213,0.002619589,0.001012795,0.0006800429,0.006423963,0.1677253,0.0008011236,0.01211716,0.1694188],"study_design_scores_gemma":[0.4138399,0.5511423,0.01512344,0.00006159046,0.0008436349,0.0009981053,0.0001081742,0.002181215,0.009108604,0.0003563192,0.006186535,0.00005003107],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889143,0.003338106,0.0008231632,0.0005514011,0.0001109811,0.002113227,0.001636446,0.0001358085,0.002376565],"genre_scores_gemma":[0.987995,0.002289198,0.002016093,0.0007215476,0.0001085764,0.001747386,0.002282276,0.00003803019,0.002801957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003831786,"threshold_uncertainty_score":0.01281857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611992263539499,"score_gpt":0.3019681617558525,"score_spread":0.2858482391204575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}