{"id":"W4389243936","doi":"10.1182/blood-2023-190089","title":"Pharmacokinetic-Targeting and Dose-Adjustment of I.V. Busulfan for Myeloablative Conditioning in Allogeneic Hematopoietic Cell Transplantation","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Busulfan; Medicine; Fludarabine; Total body irradiation; Transplantation; Internal medicine; Anti-thymocyte globulin; Area under the curve; Gastroenterology; Hematopoietic stem cell transplantation; Regimen; Pharmacokinetics; Proportional hazards model; Univariate analysis; Urology; Oncology; Surgery; Chemotherapy; Multivariate analysis; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007173746,0.0002002417,0.0002448495,0.0001488723,0.00009477959,0.0002988461,0.0001508633,0.0001304803,0.0004088329],"category_scores_gemma":[0.001131996,0.00008502515,0.0001623206,0.0001913629,0.0001624203,0.0001379108,0.0001408772,0.0003352354,0.00009051598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005190025,"about_ca_system_score_gemma":0.0004723207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004719109,"about_ca_topic_score_gemma":0.0005844159,"domain_scores_codex":[0.9997655,0.0001030395,0.000017816,0.00003004374,0.00006442928,0.00001920741],"domain_scores_gemma":[0.9997332,0.000067165,0.000143623,0.00001544599,0.00001556139,0.00002500284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01648302,0.001559064,0.2856701,0.0004560088,0.0004981841,0.0003045771,0.00016481,0.02383817,0.3297898,0.0006121245,0.001228644,0.3393955],"study_design_scores_gemma":[0.0009364678,0.02663771,0.6907111,0.0001056787,0.000573974,0.003449725,0.0001261186,0.04042906,0.227502,0.001044494,0.008438148,0.00004547934],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995097,0.002088735,0.00222491,0.00008617333,0.000009797417,0.00003715892,0.00006476071,0.00002431558,0.0003670088],"genre_scores_gemma":[0.9983793,0.0004468875,0.0009176565,0.00002923605,0.000009391358,0.00001617029,0.00008395954,0.00000407008,0.0001131737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007173746,"threshold_uncertainty_score":0.003793895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194323155127938,"score_gpt":0.2829035870268979,"score_spread":0.2634712715141041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}