{"id":"W4389244706","doi":"10.1158/2326-6074.tumimm23-b045","title":"Abstract B045: EV-mediated immune modulation of CD8+ T cells in renal cell carcinoma","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immune system; Cancer research; Renal cell carcinoma; Flow cytometry; CD8; Immunotherapy; Cytotoxic T cell; Biology; Downregulation and upregulation; Cell culture; Immunology; Medicine; Chemistry; Pathology; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451739,0.0002433328,0.0002960694,0.0001760466,0.0001379428,0.000243911,0.000185091,0.0003410301,0.003342869],"category_scores_gemma":[0.0000868346,0.00006859141,0.0003158194,0.000146633,0.0001070167,0.0001399749,0.0001351265,0.000397915,0.0007274284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001754061,"about_ca_system_score_gemma":0.00016812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003916574,"about_ca_topic_score_gemma":0.0002531132,"domain_scores_codex":[0.999895,0.00002338871,0.00001028889,0.00001828552,0.00002462379,0.00002841759],"domain_scores_gemma":[0.9999638,0.000008568061,0.000005977815,0.000004054374,0.000007793344,0.000009935286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000964843,0.0001926727,0.0005465238,0.0002582291,0.00001790338,0.0001001653,0.00002723517,0.0002099516,0.9887798,0.000089749,0.000355222,0.00845771],"study_design_scores_gemma":[0.0001440827,0.004389249,0.00999442,0.00002751754,0.00006664701,0.0008093543,0.00005960682,0.001053933,0.973799,0.00008099234,0.009567324,0.000007920753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907656,0.004603673,0.001447965,0.0001349483,0.0001316512,0.00004358642,0.0004489108,0.00006165134,0.002362059],"genre_scores_gemma":[0.9924887,0.001559974,0.001377315,0.000105361,0.00005638776,0.00005793121,0.001049362,0.00001636296,0.003288409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003342869,"threshold_uncertainty_score":0.01118302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03481382890091826,"score_gpt":0.3363016341544896,"score_spread":0.3014878052535713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}