{"id":"W4389245104","doi":"10.1021/acsnano.3c07706","title":"Cyclophospholipids Enable a Protocellular Life Cycle","year":2023,"lang":"en","type":"article","venue":"ACS Nano","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Università degli Studi di Trento; Natural Sciences and Engineering Research Council of Canada; European Commission; Gordon and Betty Moore Foundation; Simons Foundation; Horizon 2020 Framework Programme; Alfred P. Sloan Foundation; Howard Hughes Medical Institute","keywords":"Protocell; Biology; Abiogenesis; Nucleic acid; Artificial cell; Nucleotide; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008256823,0.0002298922,0.00007036463,0.0002127717,0.0002130285,0.0004711517,0.0001515024,0.0003915747,0.002421696],"category_scores_gemma":[0.000202298,0.0001658429,0.00009836881,0.0001080362,0.0002893983,0.0004696224,0.0004369331,0.0005110016,0.0006010028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002838728,"about_ca_system_score_gemma":0.0001689244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003063687,"about_ca_topic_score_gemma":0.0004553094,"domain_scores_codex":[0.9999369,0.000008145767,0.000003148961,0.00001497616,0.00002775594,0.000009101962],"domain_scores_gemma":[0.9999329,0.0000232784,0.00001007004,0.000009366282,0.00001106097,0.00001339158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000273226,0.000003623451,0.0001219229,0.00003002281,0.000002512614,0.00006686729,0.00001777982,0.0001779727,0.9934963,0.002563291,0.0001906766,0.003301632],"study_design_scores_gemma":[0.000005465575,0.0000224316,0.0004477059,0.000005346261,0.000003624817,0.0001084487,0.0000161021,0.001276149,0.9860331,0.0007965398,0.01128022,0.000004839392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8843581,0.004015956,0.07351393,0.002109153,0.0002878576,0.00007943952,0.0009620309,0.001164665,0.03350895],"genre_scores_gemma":[0.9661047,0.001580224,0.02481201,0.0001888405,0.00002311063,0.00004031811,0.0002358478,0.00007888935,0.00693608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002421696,"threshold_uncertainty_score":0.008101404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124852293767855,"score_gpt":0.2398406060598736,"score_spread":0.228592083122195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}