{"id":"W4389245104","doi":"10.1021/acsnano.3c07706","title":"Cyclophospholipids Enable a Protocellular Life Cycle","year":2023,"lang":"en","type":"article","venue":"ACS Nano","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Università degli Studi di Trento; Natural Sciences and Engineering Research Council of Canada; European Commission; Gordon and Betty Moore Foundation; Simons Foundation; Horizon 2020 Framework Programme; Alfred P. Sloan Foundation; Howard Hughes Medical Institute","keywords":"Protocell; Biology; Abiogenesis; Nucleic acid; Artificial cell; Nucleotide; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001326059,0.0001209126,0.0001428874,0.00006108093,0.0001651284,0.00004779872,0.0001623504,0.00003571227,0.001169259],"category_scores_gemma":[0.000008431432,0.0001123316,0.00008194306,0.0004281152,0.00002881187,0.0001234367,0.00007605262,0.00008980233,0.002840505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001456084,"about_ca_system_score_gemma":0.00009614207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002132245,"about_ca_topic_score_gemma":5.500622e-7,"domain_scores_codex":[0.9990858,0.00001657578,0.0001740269,0.0002095491,0.0001631636,0.0003509291],"domain_scores_gemma":[0.999484,0.00001914901,0.00005170677,0.0002700767,0.00003732339,0.0001377483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006579659,0.0005560547,0.2235529,0.00009812585,0.0002861659,0.00001963255,0.0008552591,0.00156,0.02841865,0.1885579,0.54403,0.01199941],"study_design_scores_gemma":[0.0007013932,0.00004938831,0.002824177,0.00001986318,0.00001353009,3.912416e-7,0.0002301003,0.0008588889,0.01826902,0.008659693,0.9680944,0.0002791507],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383755,0.00003407336,0.0003099993,0.0006806071,0.0004594396,0.0006298616,0.00005309515,0.0002525397,0.05920483],"genre_scores_gemma":[0.9876208,0.000003783677,0.0001117088,0.0001169445,0.0007624672,0.0002470389,0.00004805085,0.00002341364,0.01106578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4240644,"threshold_uncertainty_score":0.9997438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124852293767855,"score_gpt":0.2398406060598736,"score_spread":0.228592083122195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}