{"id":"W4389246485","doi":"10.1182/blood-2023-175044","title":"Restoration of Mir-185 in Combination with BCR-ABL Downregulation By Therapeutic Delivery of siRNA with Lipid Nanoparticle Carriers Targets Drug Resistant Leukemic Stem/Progenitor Cells","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Cancer research; Progenitor cell; Dasatinib; Stem cell; Medicine; Downregulation and upregulation; Tyrosine kinase; Combination therapy; Myeloid leukemia; Philadelphia chromosome; Immunology; Pharmacology; Biology; Imatinib; Internal medicine; Cell biology; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001750297,0.0002857205,0.0002294341,0.0001553149,0.0001125892,0.0002323933,0.0001926133,0.000312696,0.0006088794],"category_scores_gemma":[0.00009934153,0.0001206111,0.0002344975,0.00009377683,0.0002236602,0.0002045217,0.0001693066,0.0003621838,0.0002396677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903966,"about_ca_system_score_gemma":0.0001997579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003877575,"about_ca_topic_score_gemma":0.0005660523,"domain_scores_codex":[0.9998572,0.00001661439,0.00001442638,0.00003507459,0.00005073605,0.00002591252],"domain_scores_gemma":[0.9999478,0.0000100567,0.00001872801,0.000005474505,0.000008814342,0.00000919667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005079144,0.00002969557,0.00007121608,0.0000442044,0.000003628386,0.00002371182,0.00001574125,0.0001135228,0.9983186,0.00008434227,0.00004103217,0.001203671],"study_design_scores_gemma":[0.000009145103,0.0002922206,0.0004302725,0.000002440147,0.00001136718,0.00006093384,0.000007338499,0.0008344462,0.9969786,0.00001451068,0.00135518,0.000003407181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880881,0.001140326,0.008426084,0.0001134214,0.00004428436,0.0001119466,0.0001726521,0.0001406683,0.001762495],"genre_scores_gemma":[0.9912429,0.000626528,0.006103795,0.00005562828,0.000009069661,0.0001137453,0.0001838904,0.00001993219,0.00164449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006088794,"threshold_uncertainty_score":0.002106965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008391813627352,"score_gpt":0.2196520200213277,"score_spread":0.2095681018850542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}