{"id":"W4389246619","doi":"10.1182/blood-2023-177808","title":"Initial Report of Part B Phase 1/2 Efficacy and Safety Results for Bruton Tyrosine Kinase Inhibitor Rilzabrutinib in Patients with Relapsed Immune Thrombocytopenia","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Thrombopoietin; Bruton's tyrosine kinase; Internal medicine; Gastroenterology; Platelet; Concomitant; Thrombopoietin receptor; Antibody; Immunology; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003304408,0.001114194,0.001150517,0.0003828346,0.0004565915,0.001130141,0.0006501792,0.001540971,0.004131134],"category_scores_gemma":[0.001567418,0.0002869569,0.0008555831,0.000350816,0.0004458448,0.0004583758,0.0003275887,0.002140382,0.001391546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008400505,"about_ca_system_score_gemma":0.001313655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007364191,"about_ca_topic_score_gemma":0.001204031,"domain_scores_codex":[0.9990686,0.0004423649,0.00009763951,0.0001001574,0.0001374654,0.0001538944],"domain_scores_gemma":[0.9985412,0.0004507141,0.0002575255,0.0001045421,0.0002581949,0.0003878464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1894367,0.02853054,0.04954977,0.00282679,0.003042161,0.004373853,0.0009126318,0.003527616,0.2302189,0.0008578306,0.09379151,0.3929318],"study_design_scores_gemma":[0.1628183,0.5468397,0.112478,0.0003475857,0.002324732,0.005084523,0.0001756305,0.00307632,0.07621129,0.0008381119,0.08967178,0.0001339819],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9155377,0.02029759,0.007204871,0.005882137,0.0007167602,0.0115748,0.01849948,0.0006673537,0.01961928],"genre_scores_gemma":[0.9465093,0.004955437,0.005927584,0.008814752,0.0009844044,0.004381674,0.02036843,0.000148493,0.007910043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004131134,"threshold_uncertainty_score":0.01747561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414532108354637,"score_gpt":0.3242810735570277,"score_spread":0.3001357524734813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}