{"id":"W4389246812","doi":"10.1182/blood-2023-173951","title":"Glofitamab Monotherapy in Relapsed or Refractory Large B-Cell Lymphoma: Extended Follow-Up from a Pivotal Phase II Study and Subgroup Analyses in Patients with Prior Chimeric Antigen Receptor T-Cell Therapy and by Baseline Total Metabolic Tumor Volume","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Internal medicine; Cytokine release syndrome; Oncology; Diffuse large B-cell lymphoma; Phases of clinical research; Lymphoma; Transplantation; Chimeric antigen receptor; Gastroenterology; Immunology; Cancer; Clinical trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003486698,0.001101325,0.002344177,0.0006046042,0.0004970858,0.001234749,0.0006213813,0.0008326704,0.001913708],"category_scores_gemma":[0.001620344,0.0004098844,0.003189293,0.0007327931,0.000403903,0.0009357749,0.0005819294,0.001531573,0.0004147927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006686533,"about_ca_system_score_gemma":0.0007643976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004874848,"about_ca_topic_score_gemma":0.001412463,"domain_scores_codex":[0.9986861,0.0004783198,0.0001241809,0.0003244549,0.0001483223,0.0002385652],"domain_scores_gemma":[0.9985126,0.0003055721,0.0004001934,0.0002521724,0.0001326363,0.0003969193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6961015,0.007097151,0.1734872,0.0009164398,0.01459959,0.0007772296,0.0004148471,0.002006683,0.03126682,0.0001419436,0.003131447,0.07005916],"study_design_scores_gemma":[0.1188563,0.1753789,0.66905,0.00014852,0.01760982,0.001607232,0.0004103817,0.002237377,0.005841754,0.0003720261,0.008317619,0.0001701047],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939966,0.002906916,0.000385959,0.0001061807,0.00003567636,0.0004789363,0.001347195,0.00002553191,0.0007168612],"genre_scores_gemma":[0.9924493,0.0007598968,0.0004750236,0.0003132599,0.00009883781,0.0004779872,0.004801263,0.00001898709,0.0006055792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003486698,"threshold_uncertainty_score":0.01843959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055679731569772,"score_gpt":0.2984440166044841,"score_spread":0.2778872192887864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}