{"id":"W4389246812","doi":"10.1182/blood-2023-173951","title":"Glofitamab Monotherapy in Relapsed or Refractory Large B-Cell Lymphoma: Extended Follow-Up from a Pivotal Phase II Study and Subgroup Analyses in Patients with Prior Chimeric Antigen Receptor T-Cell Therapy and by Baseline Total Metabolic Tumor Volume","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Internal medicine; Cytokine release syndrome; Oncology; Diffuse large B-cell lymphoma; Phases of clinical research; Lymphoma; Transplantation; Chimeric antigen receptor; Gastroenterology; Immunology; Cancer; Clinical trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006970965,0.0005233233,0.001109548,0.0006533242,0.000158062,0.00006192209,0.0001836903,0.0001380771,0.0006814797],"category_scores_gemma":[0.00008095767,0.0003952298,0.0001065871,0.001629645,0.0001078155,0.0001839188,0.0001192496,0.0003475923,0.00001622237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007190151,"about_ca_system_score_gemma":0.0002277697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092767,"about_ca_topic_score_gemma":0.00026561,"domain_scores_codex":[0.9962723,0.0004653475,0.0006672351,0.0010365,0.0007931325,0.0007655104],"domain_scores_gemma":[0.9985484,0.0002073883,0.0002021254,0.0006207846,0.0001108063,0.0003104458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03499489,0.07613132,0.4747262,0.00004709159,0.0007380844,0.000383338,0.004973066,4.494057e-7,0.3692576,1.853374e-7,0.0003745904,0.03837325],"study_design_scores_gemma":[0.3934464,0.01629589,0.5675602,0.00007135294,0.0002178987,0.000007783371,0.001540357,0.000558157,0.01852095,0.000002463246,0.001203883,0.0005746597],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905719,0.00611945,0.000003795063,0.00005355273,0.00008110221,0.002726563,0.0003018331,0.0001106491,0.00003116015],"genre_scores_gemma":[0.9947625,0.001728487,0.0002569603,0.000117407,0.00008826177,0.0002032687,0.0003701616,0.0001451292,0.002327835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3584515,"threshold_uncertainty_score":0.99985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055679731569772,"score_gpt":0.2984440166044841,"score_spread":0.2778872192887864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}