{"id":"W4389246839","doi":"10.1182/blood-2023-190015","title":"Patient-Reported Outcomes: Danicopan As Add-on Therapy to Ravulizumab or Eculizumab Versus Placebo in Patients with Paroxysmal Nocturnal Hemoglobinuria and Clinically Significant Extravascular Hemolysis","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Eculizumab; Internal medicine; Placebo; Anemia; Clinical trial; Hemolysis; Gastroenterology; Pediatrics; Surgery; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003321544,0.0004303357,0.0006966343,0.000278949,0.0001678058,0.00004727735,0.0003032958,0.0001881454,0.0007572242],"category_scores_gemma":[0.0004360005,0.0003013468,0.0001555216,0.0004990248,0.0001073521,0.00007368046,0.0001531226,0.00025882,0.0003883371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000675722,"about_ca_system_score_gemma":0.0001901949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001224726,"about_ca_topic_score_gemma":0.00007284153,"domain_scores_codex":[0.996931,0.0004250536,0.0009450061,0.0008183433,0.0002361176,0.0006444527],"domain_scores_gemma":[0.9981478,0.0005683908,0.0003092508,0.0007312,0.0001097534,0.0001335512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06135198,0.003791596,0.9169511,0.00005178954,0.003028441,0.0004487634,0.001254043,0.00006302887,0.00269988,0.00003248379,0.001970265,0.008356625],"study_design_scores_gemma":[0.1175051,0.01092242,0.8625859,0.0001961379,0.0003900851,0.0000280882,0.0009908627,0.000003164934,0.003712103,0.00001893101,0.002861943,0.0007852976],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970031,0.0001334773,0.000003729378,0.0001155774,0.0004652239,0.001826476,0.00009823395,0.0001650017,0.0001892293],"genre_scores_gemma":[0.9989144,0.00002574667,0.00006297453,0.0002303899,0.0000205759,0.0002249134,0.0002589456,0.00004946612,0.0002125752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05615311,"threshold_uncertainty_score":0.9999439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02236022581142936,"score_gpt":0.2780826313466097,"score_spread":0.2557224055351803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}