{"id":"W4389246847","doi":"10.1182/blood-2023-182027","title":"Preliminary Results from a Phase 1b/2 Open-Label, Multicenter, Dose Optimization Clinical Study of the Safety, Tolerability, and Pharmacokinetic (PK) and Pharmacodynamic (PD) Profiles of Cfi-400945 As a Single Agent or in Combination with Azacitidine in Patients (Pts) with Acute Myeloid Leukemia, Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia (TWT-202)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Pharmacodynamics; Pharmacokinetics; Internal medicine; Oncology; Pharmacology; Azacitidine; Adverse effect; Neutropenia; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002849579,0.001756646,0.001745692,0.0004455568,0.0005523908,0.001045358,0.001082689,0.001373809,0.00535294],"category_scores_gemma":[0.001807804,0.0005527652,0.001261698,0.0006528588,0.0008742932,0.001124075,0.0003655209,0.004158868,0.001022535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001092417,"about_ca_system_score_gemma":0.001682236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009915422,"about_ca_topic_score_gemma":0.003393647,"domain_scores_codex":[0.9991466,0.0004382775,0.00005004141,0.0001366329,0.00009856364,0.0001298545],"domain_scores_gemma":[0.9987565,0.0003038571,0.0002656863,0.0001509981,0.0001024925,0.0004203067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4360807,0.1382696,0.01070706,0.001345526,0.001931953,0.0005797188,0.001019432,0.00745723,0.1891711,0.0005538242,0.01184037,0.2010434],"study_design_scores_gemma":[0.2632779,0.6831716,0.02670634,0.0000544968,0.0006754458,0.0007578512,0.0001101308,0.00178981,0.01625904,0.0004569475,0.006673818,0.00006654082],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814873,0.001951577,0.002605158,0.0007608741,0.00007891555,0.005556429,0.004407336,0.0002409378,0.002911537],"genre_scores_gemma":[0.9709834,0.001718231,0.008719863,0.001511782,0.0001611367,0.005286417,0.007782421,0.0001443035,0.003692424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00535294,"threshold_uncertainty_score":0.01790738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04174852668020341,"score_gpt":0.3510632918681256,"score_spread":0.3093147651879222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}