{"id":"W4389246864","doi":"10.1182/blood-2023-190534","title":"Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; SickKids Foundation; Hospital for Sick Children; BC Children's Hospital; University of Toronto","funders":"","keywords":"Medicine; Thalassemia; Fetal hemoglobin; Clinical endpoint; Internal medicine; Blood transfusion; Pediatrics; Gastroenterology; Surgery; Clinical trial; Biology; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747409,0.0001231474,0.0002078287,0.0001048358,0.0001019744,0.000009961797,0.00006746617,0.0001797662,0.0001147845],"category_scores_gemma":[0.00006235779,0.00009962646,0.0001490245,0.000276532,0.00002617407,0.00002239179,0.00001900354,0.0001321408,0.0002219325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001446078,"about_ca_system_score_gemma":0.00009272419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001958468,"about_ca_topic_score_gemma":0.000006212274,"domain_scores_codex":[0.9990228,0.00001276106,0.0002000781,0.0002470656,0.0001920651,0.0003252074],"domain_scores_gemma":[0.9995121,0.00005411117,0.00002712633,0.0002190804,0.00004842429,0.0001391499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005821213,0.004033226,0.03419791,0.001441568,0.001417524,0.001175929,0.002665418,0.0001697082,0.8459238,0.001355411,0.04354206,0.06349531],"study_design_scores_gemma":[0.1037058,0.005429173,0.1146256,0.001224153,0.005482973,0.001744915,0.006034884,0.004894333,0.4874226,0.003707017,0.2633705,0.002358011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899094,0.0005816728,0.0002375754,0.002102206,0.0003157282,0.0007133517,0.00002737421,0.0003595238,0.005753196],"genre_scores_gemma":[0.9904261,0.001087534,0.000426813,0.0003127698,0.0001784644,0.0001062873,0.0000919537,0.0000476721,0.00732247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3585013,"threshold_uncertainty_score":0.4062649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440544004097374,"score_gpt":0.2585640299461746,"score_spread":0.2441585899052008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}