{"id":"W4389246885","doi":"10.1182/blood-2023-185110","title":"Clinical Characteristics, Management, and Allogeneic Hematopoietic Cell Transplantation of Patients with Toll-like Receptor 8 Gain-of-Function Mutations","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Immunology; Medicine; Neutropenia; Transplantation; Congenital Neutropenia; Hypogammaglobulinemia; Bone marrow; Myeloid; Hematopoietic stem cell transplantation; Biology; Internal medicine; Antibody; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041216,0.0004381007,0.0003912016,0.0006026447,0.0004537438,0.0002962018,0.0001977849,0.0004945419,0.0008191948],"category_scores_gemma":[0.00110406,0.000123834,0.0002717084,0.0004295844,0.0002705377,0.0002567339,0.00024748,0.0004123549,0.0002554695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000241883,"about_ca_system_score_gemma":0.0002225417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005684791,"about_ca_topic_score_gemma":0.000578114,"domain_scores_codex":[0.9997676,0.00004093508,0.00003510973,0.00004334522,0.00004383476,0.00006915307],"domain_scores_gemma":[0.9994766,0.0001087581,0.000136237,0.00001624378,0.00004000215,0.0002221664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003565679,0.0001233807,0.946879,0.00002094488,0.00003022233,0.03544161,0.0002632646,0.0004114778,0.004938448,0.0001345608,0.0005474089,0.01085315],"study_design_scores_gemma":[0.00004026798,0.00101262,0.7822496,0.00003235906,0.00004466134,0.2127812,0.0003621339,0.0007144974,0.001030043,0.000190408,0.001519097,0.00002317718],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967521,0.0007152321,0.0001940303,0.000142934,0.000008555036,0.00001755383,0.00009941176,0.0000100273,0.002060079],"genre_scores_gemma":[0.9988966,0.000279759,0.0001826445,0.0001120831,0.00003316343,0.00001737799,0.0001968799,0.000005161714,0.0002762343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008191948,"threshold_uncertainty_score":0.002740502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007403220824039343,"score_gpt":0.2303426500580569,"score_spread":0.2229394292340175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}