{"id":"W4389246989","doi":"10.1182/blood-2023-178933","title":"Idecabtagene Vicleucel (ide-cel) Versus Standard (std) Regimens in Patients (pts) with Triple-Class-Exposed (TCE) Relapsed and Refractory Multiple Myeloma (RRMM): Updated Analysis from KarMMa-3","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Calgary","funders":"","keywords":"Daratumumab; Medicine; Lenalidomide; Internal medicine; Regimen; Interim analysis; Clinical endpoint; Oncology; Progression-free survival; Population; Multiple myeloma; Neutropenia; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0022522,0.0003443725,0.001145893,0.0003463853,0.0001076456,0.0009115579,0.0005154769,0.0003452953,0.001547314],"category_scores_gemma":[0.001606255,0.0002244861,0.002207118,0.0005447268,0.0002205885,0.0005208505,0.0003049966,0.001197179,0.0001672697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006463875,"about_ca_system_score_gemma":0.0004689799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007172737,"about_ca_topic_score_gemma":0.002979241,"domain_scores_codex":[0.9993415,0.0003236961,0.00004911123,0.0001173579,0.00009247087,0.00007588071],"domain_scores_gemma":[0.9988744,0.0004062758,0.0004443276,0.00008278384,0.00005026575,0.0001420344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6224108,0.00210906,0.08231396,0.002928023,0.01720734,0.0002132294,0.0002182902,0.004989444,0.01020634,0.000414746,0.005133432,0.2518552],"study_design_scores_gemma":[0.2621966,0.2086505,0.4529097,0.0008249659,0.03875471,0.001484499,0.0002175816,0.007111824,0.006548036,0.001353109,0.01982992,0.0001186315],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792193,0.01499941,0.0006419898,0.0003539067,0.00008521293,0.0003250554,0.002488459,0.00005665588,0.001830119],"genre_scores_gemma":[0.9927326,0.003425115,0.0005575611,0.0003218733,0.00008580182,0.0002056667,0.00208169,0.00001244251,0.000577254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022522,"threshold_uncertainty_score":0.01191097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085364430622874,"score_gpt":0.2679152240224768,"score_spread":0.2470615797162481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}