{"id":"W4389247119","doi":"10.1182/blood-2023-188080","title":"The Impact of Soluble BCMA and BCMA Gain on Anti-BCMA Immunotherapies in Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Biology; Chimeric antigen receptor; Antigen; Cancer research; NFAT; Molecular biology; T cell; Immunology; Gene; Immune system; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002113904,0.0002773971,0.0003421885,0.0002042425,0.0001145486,0.0003940758,0.0001745061,0.0003302991,0.0009134981],"category_scores_gemma":[0.0001618158,0.0001108094,0.0002042841,0.0002250431,0.0001795465,0.0002496973,0.0001850416,0.0006631577,0.0001721387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003344864,"about_ca_system_score_gemma":0.0002459569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001566144,"about_ca_topic_score_gemma":0.001881138,"domain_scores_codex":[0.9997746,0.00003911986,0.00001734586,0.00003046129,0.00009218157,0.00004621537],"domain_scores_gemma":[0.9999255,0.00002167437,0.00001457181,0.000009479772,0.00001144483,0.0000173138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001734038,0.00009316189,0.0001634752,0.00003713386,0.000006252986,0.00002856176,0.00001234896,0.0001886643,0.9973999,0.00006513586,0.00003656412,0.001795469],"study_design_scores_gemma":[0.00002776017,0.001369292,0.002652023,0.000004277276,0.00002891067,0.0001479401,0.00001987979,0.001185647,0.9930112,0.00002835906,0.001521366,0.000003401859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996914,0.001561105,0.0006909287,0.00004918026,0.00001760943,0.00002102228,0.0001297602,0.00002261525,0.0005936891],"genre_scores_gemma":[0.9970108,0.0009168969,0.001016843,0.0000286411,0.000009780489,0.0000187443,0.0002081697,0.000009196466,0.0007808793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566144,"threshold_uncertainty_score":0.003114104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03253788870408592,"score_gpt":0.3233113030359155,"score_spread":0.2907734143318296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}