{"id":"W4389247146","doi":"10.1182/blood-2023-190494","title":"SWI/SNF Chromatin Remodeling Complex Orchestrates Sequential Binding of Key Transcription Factors in B Cells and Restricts Aggressive Lymphoma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency; Spinal Cord Injury BC","funders":"","keywords":"ARID1A; Germinal center; Chromatin; Chromatin remodeling; Biology; Lymphoma; Molecular biology; Diffuse large B-cell lymphoma; Aggressive lymphoma; B cell; Cancer research; Transcription factor; Follicular lymphoma; Mutation; Immunology; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327256,0.0001358913,0.0001697459,0.00009773271,0.00005110237,0.00001912515,0.00009293209,0.0001337505,0.000004720374],"category_scores_gemma":[0.00003841072,0.0001335558,0.00005662688,0.0001950289,0.000049385,0.000005487035,0.0000381152,0.00004769693,0.000001951754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001223865,"about_ca_system_score_gemma":0.00007144879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001413675,"about_ca_topic_score_gemma":0.00004361575,"domain_scores_codex":[0.9990758,0.00004990872,0.0002721625,0.0002701496,0.0001228584,0.000209165],"domain_scores_gemma":[0.9996108,0.00001663693,0.0001380478,0.0001484567,0.00003718912,0.00004885173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001934251,0.00007278728,0.001531763,0.00007824811,0.00002562451,0.000006516615,0.0003269117,0.0009026239,0.9962559,0.00000486716,0.00004056375,0.0007348376],"study_design_scores_gemma":[0.001626174,0.0001326716,0.007623326,0.0001449371,0.00003379204,0.0000112427,0.0003989951,0.007969555,0.9817724,0.00006317666,0.00005113018,0.0001725906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991491,0.0003642741,0.0001155903,0.00001635209,0.00006731594,0.0001172498,0.00004759475,0.00002435248,0.00009814482],"genre_scores_gemma":[0.9985223,0.0005471824,0.0006033926,0.000008486059,0.00005303351,0.000005999763,0.0002016687,0.00001979198,0.00003808785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0144835,"threshold_uncertainty_score":0.5446246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03410324158100014,"score_gpt":0.266288934618951,"score_spread":0.2321856930379508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}