{"id":"W4389247146","doi":"10.1182/blood-2023-190494","title":"SWI/SNF Chromatin Remodeling Complex Orchestrates Sequential Binding of Key Transcription Factors in B Cells and Restricts Aggressive Lymphoma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency; Spinal Cord Injury BC","funders":"","keywords":"ARID1A; Germinal center; Chromatin; Chromatin remodeling; Biology; Lymphoma; Molecular biology; Diffuse large B-cell lymphoma; Aggressive lymphoma; B cell; Cancer research; Transcription factor; Follicular lymphoma; Mutation; Immunology; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076755,0.0002839751,0.000205352,0.0003859381,0.0001558523,0.0004513111,0.0001583835,0.0002274041,0.001374077],"category_scores_gemma":[0.00009164838,0.0002165849,0.0001470214,0.0001330852,0.0003336148,0.0002619602,0.0003799488,0.0003948281,0.0006971708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002826338,"about_ca_system_score_gemma":0.0001454239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006038607,"about_ca_topic_score_gemma":0.001085588,"domain_scores_codex":[0.9998093,0.00001879272,0.00001072213,0.00005065322,0.00004699634,0.00006353622],"domain_scores_gemma":[0.9998717,0.000007024861,0.00004059062,0.000008521957,0.000009517099,0.00006254971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000113596,0.0000103347,0.0009172881,0.00001616035,0.000002851025,0.0000401117,0.00001995164,0.0000328452,0.9976337,0.00009072276,0.00004187645,0.001080616],"study_design_scores_gemma":[0.00003508989,0.0003470434,0.1160369,0.00001899374,0.00002597342,0.0007201809,0.0002514406,0.001405021,0.8731456,0.0003198933,0.007679563,0.00001423735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994396,0.001993546,0.00151861,0.00005045084,0.00001334754,0.00001237533,0.0003152267,0.0001173473,0.001583108],"genre_scores_gemma":[0.9959324,0.0007627681,0.0007191644,0.00003339339,0.000008300579,0.00001598994,0.0004311383,0.00002987386,0.002066964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001374077,"threshold_uncertainty_score":0.00459671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03410324158100014,"score_gpt":0.266288934618951,"score_spread":0.2321856930379508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}