{"id":"W4389247332","doi":"10.1182/blood-2023-190331","title":"A Zebrafish Model of Parn-Deficiency Reveals Conserved Mechanisms Underlying Marrow Failure and Opportunities for Therapeutic Amelioration of Hematopoiesis","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; SickKids Foundation; AGADA Biosciences; Hospital for Sick Children; Agricultural Research Institute of Ontario","funders":"","keywords":"Dyskeratosis congenita; Biology; Zebrafish; Cancer research; Bone marrow failure; Genetics; Danio; Cell biology; Haematopoiesis; Stem cell; Telomerase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000206985,0.0005709567,0.0003449163,0.0005632363,0.0003871007,0.0002589898,0.0004444441,0.0008190852,0.004559564],"category_scores_gemma":[0.0001233167,0.0003113173,0.0004372804,0.0001590162,0.0005152021,0.0003606272,0.0003619108,0.001171886,0.0008555227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007133373,"about_ca_system_score_gemma":0.0006008527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002703154,"about_ca_topic_score_gemma":0.005296091,"domain_scores_codex":[0.9997886,0.00001465155,0.00001751893,0.00006579253,0.00007403583,0.00003950702],"domain_scores_gemma":[0.9998752,0.00001383263,0.00003580483,0.00001353064,0.00001627771,0.00004537249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008494026,0.00002160051,0.0001384028,0.00004895035,0.000004662581,0.0003017635,0.00002871882,0.0001614443,0.997117,0.0006759749,0.0001752371,0.001241268],"study_design_scores_gemma":[0.0001357492,0.0006978399,0.006637547,0.00004500497,0.00005773746,0.002101865,0.00009867804,0.003605705,0.9728152,0.0004586792,0.01331366,0.00003225717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9422588,0.002038784,0.03515497,0.001163399,0.0002730627,0.0002801526,0.004516126,0.001264596,0.0130501],"genre_scores_gemma":[0.9545988,0.001207533,0.02107134,0.0002274302,0.00001616657,0.0003770045,0.00130158,0.0001697245,0.0210304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004559564,"threshold_uncertainty_score":0.01525331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1394447992235694,"score_gpt":0.3008427787790765,"score_spread":0.1613979795555071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}