{"id":"W4389247352","doi":"10.1182/blood-2023-172873","title":"CD56 brightCD16 -Perforin - regulatory Natural Killer Cells Associated with the Suppression of Chronic Graft-Versus-Host Disease Prevent CD4 + T Cell Proliferation through PD-1 and LAG-3 Dependent Pathways","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Perforin; Interleukin 21; Granzyme; Biology; Immunology; Cytotoxic T cell; Granzyme B; Population; CD8; Cell sorting; NK-92; Graft-versus-host disease; Interleukin-7 receptor; T cell; Cell biology; Stem cell; Immune system; Flow cytometry; IL-2 receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658744,0.0002959202,0.0002711241,0.0001916982,0.0001223253,0.0002831603,0.0001156247,0.0001542382,0.001744731],"category_scores_gemma":[0.0001427097,0.00009416511,0.0002054577,0.0001024585,0.0002343542,0.0001491848,0.0002633641,0.0004437977,0.0004057527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001485504,"about_ca_system_score_gemma":0.0001527874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007307546,"about_ca_topic_score_gemma":0.0001369919,"domain_scores_codex":[0.9998879,0.00001782584,0.00001178729,0.00002503701,0.00002162937,0.00003574858],"domain_scores_gemma":[0.9998817,0.00001494952,0.00004562493,0.00001403094,0.00001022807,0.00003337316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002769336,0.00003797602,0.002439388,0.00004784881,0.000006297443,0.00008645729,0.00001864919,0.00004958895,0.9937803,0.00007800441,0.00004491162,0.00313354],"study_design_scores_gemma":[0.0001795229,0.002063402,0.09280484,0.00004976048,0.0001130019,0.00312873,0.0001817275,0.002187649,0.8921525,0.0005946268,0.006531205,0.0000129249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967211,0.0009168595,0.00134032,0.00004392597,0.00001473127,0.00002824958,0.00009600979,0.00005970566,0.0007792238],"genre_scores_gemma":[0.9973583,0.0002919196,0.001262307,0.00005912804,0.00001268906,0.00003042368,0.000205264,0.00001251535,0.0007674962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001744731,"threshold_uncertainty_score":0.005836666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008848144869105155,"score_gpt":0.2043990923397531,"score_spread":0.1955509474706479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}