{"id":"W4389247484","doi":"10.1182/blood-2023-181181","title":"Predictors of Cytokine Release Syndrome and Neurotoxicity in Patients with Large B-Cell Lymphoma and Their Impact on Survival","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Eurostars; Legend Biotech; Pharmacyclics; Aptitude Health; Daiichi Sankyo Europe; National Cancer Institute; Gilead Sciences; Servier; Juno Therapeutics; Astellas Pharma; Swedish Orphan Biovitrum; Omeros Corporation; BeiGene; Incyte; CTI Biopharma; bluebird bio; Jazz Pharmaceuticals; Fred Hutchinson Cancer Research Center; Karyopharm Therapeutics; Atara Biotherapeutics; Massachusetts General Hospital; Leukemia and Lymphoma Society; Kite Pharma; Society for Immunotherapy of Cancer; AstraZeneca; Cidara Therapeutics; MorphoSys; Celgene; Eli Lilly and Company; Bristol-Myers Squibb; Amgen","keywords":"Medicine; Cytokine release syndrome; Internal medicine; Proportional hazards model; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005070635,0.0001615235,0.0002216422,0.0004653534,0.0002408192,0.0004112468,0.0001761094,0.0002157518,0.00127256],"category_scores_gemma":[0.001662976,0.0001033779,0.000305795,0.0006261432,0.0001981373,0.000346075,0.000281456,0.0004391446,0.0001749267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002151602,"about_ca_system_score_gemma":0.0002897048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008242878,"about_ca_topic_score_gemma":0.001135134,"domain_scores_codex":[0.999751,0.00005932938,0.00003667608,0.0000433479,0.00005429427,0.00005522459],"domain_scores_gemma":[0.9982702,0.0003497023,0.0009101473,0.00005656029,0.0001315022,0.0002819889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007781723,0.000005571243,0.9993228,0.000001790324,0.000008264501,0.00004778888,0.000005513957,0.00003285208,0.00004993919,0.000003576262,0.00001856215,0.0004255456],"study_design_scores_gemma":[0.000005291416,0.0001265382,0.9984941,0.000004602806,0.00002303324,0.0007761301,0.00006149361,0.0002384823,0.0000767122,0.00001847045,0.0001727976,0.000002287206],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989349,0.0004036375,0.00006841557,0.00002889051,0.000003615589,0.000003605239,0.0001820885,0.000002513835,0.0003722593],"genre_scores_gemma":[0.9996338,0.00007267921,0.00003409539,0.000007151663,0.000006343876,0.000002813124,0.0001925589,7.263297e-7,0.00004983135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127256,"threshold_uncertainty_score":0.004257143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01048107823113658,"score_gpt":0.2478609780233672,"score_spread":0.2373798997922306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}