{"id":"W4389247677","doi":"10.1182/blood-2023-188649","title":"Once-Weekly Efanesoctocog Alfa Prophylaxis Provided High Sustained Factor VIII Activity Levels, Independent of Blood Group, in Children <12 Years of Age with Severe Hemophilia A","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster Children's Hospital","funders":"","keywords":"Medicine; Partial thromboplastin time; Internal medicine; Population; Clotting factor; Cryoprecipitate; Gastroenterology; Breakthrough bleeding; Bleed; Coagulation; Platelet; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004784236,0.0002299737,0.0005069934,0.0001370905,0.0002277482,0.0003198985,0.0001765143,0.0002662082,0.001559332],"category_scores_gemma":[0.0007455546,0.0001660312,0.0003918238,0.0001791583,0.0002127481,0.0003153891,0.0002148154,0.0005105882,0.000218682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003890744,"about_ca_system_score_gemma":0.0005994713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001688689,"about_ca_topic_score_gemma":0.002968469,"domain_scores_codex":[0.9997978,0.00005947361,0.00001254249,0.00005260254,0.00002771872,0.00004984979],"domain_scores_gemma":[0.9996853,0.0000672526,0.0001099258,0.00001451409,0.00001925089,0.0001038131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1632185,0.01318497,0.5811273,0.0008163677,0.000732817,0.001429634,0.001150877,0.0022555,0.05666948,0.0003662843,0.005305956,0.1737423],"study_design_scores_gemma":[0.01533364,0.2065586,0.7524717,0.0001520307,0.0005922594,0.003461107,0.0005530411,0.001930446,0.009802664,0.0001719569,0.008922482,0.00005009172],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984776,0.0005877849,0.0001286851,0.00004419171,0.000008138209,0.00005715484,0.0003762204,0.00001087792,0.000309319],"genre_scores_gemma":[0.9982656,0.0003367864,0.0003829135,0.0000720975,0.00001652209,0.0001115879,0.0003917345,0.000003617414,0.0004191057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001688689,"threshold_uncertainty_score":0.00521642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02467584443560855,"score_gpt":0.2735127056332968,"score_spread":0.2488368611976882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}