{"id":"W4389247802","doi":"10.1182/blood-2023-189567","title":"A High-Risk Subgroup Multiple Myeloma Classification Based on the Detection of PR Minor Subclones","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Multiple myeloma; Bone marrow; RNA; Gene signature; Gene expression; Biology; Gene; Transcriptome; Molecular biology; Cancer research; Internal medicine; Computational biology; Oncology; Medicine; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001203265,0.0007279633,0.0006692478,0.002059402,0.0005310114,0.001364537,0.0006002864,0.0005584054,0.002446827],"category_scores_gemma":[0.001441572,0.0001965011,0.0008931098,0.0009807115,0.0004407995,0.0004698575,0.001084562,0.0007147684,0.001201072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003883681,"about_ca_system_score_gemma":0.0004963133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002009389,"about_ca_topic_score_gemma":0.001859588,"domain_scores_codex":[0.9991202,0.0001248561,0.0001096392,0.0002020828,0.0003077679,0.0001354163],"domain_scores_gemma":[0.9993562,0.0001104038,0.0001579325,0.00009691931,0.0001822221,0.00009623708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004145233,0.0001415909,0.7393855,0.0003805854,0.0004310328,0.0008134419,0.0007144158,0.001669882,0.1020462,0.001400738,0.005051715,0.1438196],"study_design_scores_gemma":[0.0003946822,0.001610157,0.8862665,0.0001836409,0.001189103,0.009452947,0.0009714345,0.0245575,0.04115355,0.00681442,0.02726491,0.0001410966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603259,0.003348393,0.02484179,0.0004940871,0.0001057715,0.0006953346,0.002723688,0.0008962252,0.006568825],"genre_scores_gemma":[0.9765794,0.0006679839,0.01636995,0.0002284252,0.00008699213,0.0002422678,0.003430189,0.000114986,0.002279822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002446827,"threshold_uncertainty_score":0.008185446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03507370313292706,"score_gpt":0.2737519082806611,"score_spread":0.238678205147734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}