{"id":"W4389247832","doi":"10.1182/blood-2023-178821","title":"Lymphodepletion Enables Successful BCMA CAR-T Cell Engraftment and Tumour Control in the Syngeneic Vk*MYC Model of Aggressive Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; National Research Council Canada; Canada's Michael Smith Genome Sciences Centre; University of Ottawa; Terry Fox Research Institute; University of British Columbia","funders":"","keywords":"Chimeric antigen receptor; CD28; Multiple myeloma; Antigen; Cancer research; Immunology; Biology; T cell; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002476099,0.0003192958,0.0003290144,0.0004019042,0.0002083768,0.0004204485,0.0002974739,0.0004128282,0.001462538],"category_scores_gemma":[0.0001189572,0.0001183571,0.0002598007,0.0002121194,0.0002776373,0.0002295724,0.0002448444,0.00109843,0.0003696964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004901867,"about_ca_system_score_gemma":0.0002652953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002679002,"about_ca_topic_score_gemma":0.002475141,"domain_scores_codex":[0.9996836,0.00003630474,0.00004148877,0.00007733793,0.00007885569,0.00008244483],"domain_scores_gemma":[0.9998009,0.0000537194,0.00003982686,0.00003017733,0.00001725043,0.00005812147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047234,0.00006083765,0.0001088696,0.00001800384,0.000003002515,0.00005825211,0.00004235552,0.0001496487,0.9985024,0.0002244675,0.00004697145,0.0006804776],"study_design_scores_gemma":[0.00001207502,0.0003059839,0.0009088165,0.000002833048,0.000006768664,0.0001476831,0.0000213724,0.001260057,0.9960607,0.00003087423,0.001240235,0.000002559736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904498,0.0003727736,0.005948238,0.00007954609,0.00003997594,0.0000884701,0.0007198418,0.0001449578,0.002156277],"genre_scores_gemma":[0.9922199,0.0002191231,0.002926363,0.0000237688,0.000006392907,0.00006678826,0.0003901705,0.00003942007,0.004108212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002679002,"threshold_uncertainty_score":0.005326807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952283326465807,"score_gpt":0.2710570736946132,"score_spread":0.2515342404299551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}