{"id":"W4389247933","doi":"10.1016/j.vaccine.2023.11.048","title":"Production, purification and immunogenicity of Gag virus-like particles carrying SARS-CoV-2 components","year":2023,"lang":"en","type":"article","venue":"Vaccine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; National Research Council Canada","funders":"National Institute of Allergy and Infectious Diseases; National Research Council Canada; National Institutes of Health","keywords":"Immunogenicity; Group-specific antigen; Virus-like particle; Capsid; Antigen; Molecular biology; Virology; Viral envelope; Biology; Transfection; Virus; Cellular immunity; Flow cytometry; Chemistry; Recombinant DNA; Cell culture; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004596491,0.0005922269,0.0002754022,0.0002732576,0.0002601024,0.0004604007,0.0003003457,0.0003827755,0.0007933253],"category_scores_gemma":[0.0004050143,0.0002887176,0.0004671441,0.0002971593,0.0002175224,0.0002894466,0.0003296529,0.0008574116,0.0005745575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003630934,"about_ca_system_score_gemma":0.0002731395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009801134,"about_ca_topic_score_gemma":0.0006310735,"domain_scores_codex":[0.9997723,0.00004953697,0.00002196916,0.00003511445,0.00005863003,0.0000625076],"domain_scores_gemma":[0.9998505,0.00004059066,0.00002501202,0.00002686489,0.00003268728,0.00002433528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001356218,0.0001013614,0.000337463,0.00002235899,0.00001184154,0.0000459818,0.00004852081,0.0002641426,0.9979,0.000105923,0.00007655959,0.000950202],"study_design_scores_gemma":[0.00006817129,0.0008510525,0.005123947,0.000008014707,0.00003149289,0.0002569244,0.00005358087,0.002027591,0.9882042,0.0001044073,0.00326077,0.000009736264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924691,0.0004706864,0.005443421,0.00007134939,0.00004705785,0.0001062921,0.0006090516,0.00003830262,0.0007446002],"genre_scores_gemma":[0.9841167,0.0004031543,0.006148131,0.00009784417,0.0000298269,0.00008870747,0.005386667,0.0000452421,0.00368373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009801134,"threshold_uncertainty_score":0.002653956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07638079719171134,"score_gpt":0.3483730406583148,"score_spread":0.2719922434666034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}