{"id":"W4389248024","doi":"10.1182/blood-2023-180233","title":"Real-World Tisagenlecleucel Outcomes in Richter-Transformed Chronic Lymphocytic Leukemia: A Center for International Blood & Marrow Transplant Research (CIBMTR) Analysis","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Hospital","funders":"","keywords":"Medicine; Cytokine release syndrome; Internal medicine; Aggressive lymphoma; Oncology; Cumulative incidence; Transplantation; Rituximab; Lymphoma; Chimeric antigen receptor; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003636726,0.0002567779,0.0003942118,0.001429267,0.0003627541,0.001062658,0.0005515461,0.000304667,0.001642828],"category_scores_gemma":[0.003708433,0.0001785083,0.0005999814,0.002065954,0.0002879369,0.0005310896,0.0009267264,0.0004956399,0.000280451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001109357,"about_ca_system_score_gemma":0.0008129625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004688769,"about_ca_topic_score_gemma":0.004099614,"domain_scores_codex":[0.9984616,0.0005540875,0.0002080417,0.0002923359,0.0002858034,0.0001981336],"domain_scores_gemma":[0.9941551,0.0009595904,0.002850974,0.0006193791,0.0008083301,0.00060662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001617179,0.0001060155,0.9936289,0.00003312407,0.0002484296,0.00007523592,0.00004948999,0.0002585894,0.0001326344,0.00006350169,0.0008229415,0.002963883],"study_design_scores_gemma":[0.0002620477,0.0006907631,0.9958019,0.00001996346,0.0002169251,0.00034634,0.0001730745,0.001002902,0.0001647323,0.00004387864,0.001263374,0.00001403252],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949806,0.0002589377,0.0001615811,0.00006767922,0.00000452109,0.00005763252,0.003914006,0.00001180221,0.0005432963],"genre_scores_gemma":[0.99275,0.00008367791,0.0001827507,0.000048776,0.00001493556,0.00006079251,0.006764303,0.0000064878,0.00008816186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004688769,"threshold_uncertainty_score":0.01923311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06427681933567496,"score_gpt":0.3831817213200614,"score_spread":0.3189049019843864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}