{"id":"W4389248130","doi":"10.1182/blood-2023-190180","title":"Single Cell Transcriptomic Analysis of B-Cell Acute Lymphoblastic Leukemia (B-ALL) Reveals Correlation between Leukemia Cell State, Genetic Alterations and Clinical Outcome","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Transcriptome; Gene; Leukemia; Genetics; Gene expression; Cell cycle; B cell; Gene expression profiling; Molecular biology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344124,0.0001236661,0.0002289522,0.0003901283,0.0001230402,0.0003038484,0.00009403186,0.0001685476,0.0008296852],"category_scores_gemma":[0.0002270938,0.0001033228,0.000122585,0.0005212414,0.0001236477,0.0001101646,0.0001735238,0.0001770012,0.0002856628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001446582,"about_ca_system_score_gemma":0.0001074652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000533002,"about_ca_topic_score_gemma":0.001164159,"domain_scores_codex":[0.9998815,0.00001053465,0.000006673142,0.00004894093,0.00003376191,0.00001855784],"domain_scores_gemma":[0.9999121,0.00002708885,0.00002382137,0.000007708611,0.00001616587,0.00001304491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002153011,0.00002112628,0.04283198,0.00009537279,0.00003914999,0.00005747682,0.00008662352,0.0002783314,0.9477177,0.00005789773,0.0002303842,0.008368477],"study_design_scores_gemma":[0.000015001,0.0003063722,0.8610489,0.00001526448,0.000110477,0.000846049,0.0002077921,0.003041843,0.1307416,0.0002736319,0.003378415,0.00001467466],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992981,0.0006415297,0.001566285,0.00004294523,0.000005275464,0.00001331414,0.004312279,0.00004794744,0.0003893053],"genre_scores_gemma":[0.9878464,0.0008199032,0.002582323,0.00006136784,0.00000885908,0.0000430184,0.007846443,0.00002693045,0.0007647602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008296852,"threshold_uncertainty_score":0.002775609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871925669843805,"score_gpt":0.273539952154337,"score_spread":0.254820695455899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}