{"id":"W4389248248","doi":"10.1182/blood-2023-180889","title":"Aberrant Splicing of <i>MBD1</i> Reshapes the Epigenome to Drive Convergent Myeloerythroid Defects in MDS","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University Health Network; University of Toronto; McMaster University","funders":"","keywords":"RNA splicing; Alternative splicing; Biology; Gene isoform; Splicing factor; Epigenetics; Genetics; Cell biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397825,0.0002645307,0.0001782798,0.0001748488,0.0001392823,0.000276411,0.0001777497,0.00018645,0.001283992],"category_scores_gemma":[0.0001062984,0.0001521025,0.0002179881,0.0001058267,0.0002152041,0.0000890743,0.0002492637,0.0005448776,0.0004561732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315885,"about_ca_system_score_gemma":0.0001875126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005187473,"about_ca_topic_score_gemma":0.00109037,"domain_scores_codex":[0.9998722,0.00001799451,0.00001326073,0.00003645705,0.00003703374,0.00002303066],"domain_scores_gemma":[0.9999127,0.00001357386,0.00002759656,0.00001200116,0.000006825522,0.00002718079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002970296,0.000007526158,0.0001939521,0.00001105513,0.000002435341,0.00003514601,0.000007937753,0.00006015999,0.9990174,0.00009081012,0.0000260879,0.0005179198],"study_design_scores_gemma":[0.00001326152,0.00008580992,0.006542522,0.000008093984,0.00001205515,0.0003694676,0.00002625103,0.001947598,0.987395,0.00005752123,0.003537611,0.000004730762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925299,0.0005255782,0.004773345,0.00008527239,0.00002816848,0.00003749583,0.000779225,0.0001509695,0.001090004],"genre_scores_gemma":[0.9953341,0.0002435223,0.002262812,0.00006789646,0.000005367961,0.00002633527,0.0006352092,0.00004971402,0.001375059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001283992,"threshold_uncertainty_score":0.004295409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02271281636424353,"score_gpt":0.2898802033748187,"score_spread":0.2671673870105752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}