{"id":"W4389248398","doi":"10.1182/blood-2023-189912","title":"A Phase 3b, Randomized, Open-Label, Parallel Group, Multicenter Study to Assess Efficacy, Safety, and Tolerability of Two Dosing Regimens of Ropeginterferon Alfa-2b-Njft (P1101) in Adult Patients with Polycythemia Vera","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Dosing; Polycythemia vera; Internal medicine; Regimen; Clinical trial; Surgery; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004296051,0.002482804,0.003628001,0.0005413043,0.0008872899,0.001735613,0.001353734,0.002704723,0.006842413],"category_scores_gemma":[0.003659457,0.001130637,0.002296811,0.0005880116,0.002293483,0.002493596,0.0006695942,0.006293831,0.001718204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001386595,"about_ca_system_score_gemma":0.002491524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009571069,"about_ca_topic_score_gemma":0.001497759,"domain_scores_codex":[0.9984012,0.0008470358,0.00007917776,0.0003267979,0.0001174106,0.0002284206],"domain_scores_gemma":[0.9961483,0.0008041027,0.000849881,0.0004336419,0.0002638396,0.001500174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.93997,0.04404435,0.001230883,0.0001613236,0.0005575108,0.00004326292,0.00009713943,0.0003214777,0.003247798,0.00007591228,0.0008562846,0.009394182],"study_design_scores_gemma":[0.8241797,0.1724486,0.002069936,0.00000917478,0.0001565371,0.00004158444,0.00002192569,0.0003179191,0.0002622404,0.0001073912,0.0003720816,0.00001298417],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850338,0.001603596,0.001236059,0.0007647709,0.0004300337,0.007571478,0.001595592,0.0001672739,0.001597307],"genre_scores_gemma":[0.9723238,0.001082525,0.00430109,0.002589648,0.0006685975,0.01375186,0.002375306,0.00006555022,0.002841694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006842413,"threshold_uncertainty_score":0.02289015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03332096510326708,"score_gpt":0.3407370386707625,"score_spread":0.3074160735674954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}