{"id":"W4389257620","doi":"10.1101/2023.11.30.569441","title":"Microglial adipose triglyceride lipase regulates neuroinflammatory and behavioural responses to LPS","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fédération pour la Recherche sur le Cerveau; Fondation pour la Recherche Médicale","keywords":"Adipose triglyceride lipase; Lipolysis; Microglia; Neuroinflammation; Inflammation; Endocrinology; Lipase; Chemistry; Internal medicine; Monoacylglycerol lipase; Lipid droplet; Triglyceride; Adipose tissue; Biology; Biochemistry; Enzyme; Medicine; Endocannabinoid system; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000202955,0.0005066292,0.0004891551,0.0004871898,0.0002445716,0.0004829634,0.0001885133,0.0005123114,0.001215599],"category_scores_gemma":[0.0001196217,0.0002079501,0.0005427455,0.0002096519,0.0004827876,0.0002337038,0.0002848564,0.0009602664,0.0005609649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005104904,"about_ca_system_score_gemma":0.0003161212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006705674,"about_ca_topic_score_gemma":0.001119105,"domain_scores_codex":[0.9997608,0.00002981245,0.00001964201,0.00004426526,0.00005617538,0.00008927768],"domain_scores_gemma":[0.9998566,0.000007526162,0.00005158652,0.00001338971,0.00002382671,0.00004696832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004846629,0.00004808497,0.0002912481,0.00004407209,0.000006714102,0.00005457358,0.00002007859,0.00003302333,0.9982756,0.00003354325,0.00003338069,0.0006749904],"study_design_scores_gemma":[0.00007417392,0.000826583,0.02443481,0.00003005277,0.00005539625,0.0003978691,0.0001847782,0.0008906896,0.9713543,0.0001852159,0.001547531,0.00001857366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922919,0.003246322,0.002000742,0.0002711565,0.00005308063,0.000060759,0.0006840938,0.0001421524,0.001249866],"genre_scores_gemma":[0.993323,0.001638533,0.00152385,0.0001529478,0.00002197249,0.0001561075,0.0005117954,0.00003451911,0.002637126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001215599,"threshold_uncertainty_score":0.004066586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01790339678176581,"score_gpt":0.2258521629334932,"score_spread":0.2079487661517274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}