{"id":"W4389258280","doi":"10.21203/rs.3.rs-3677630/v1","title":"Exploring the genetics of lithium response in bipolar disorders","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; Dalhousie University; McGill University; McGill University Health Centre","funders":"Cilag; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Eli Lilly Japan; Research Nova Scotia; Medical Research Council; Neuraxpharm; Servier; Genome Atlantic; The Wellcome Trust DBT India Alliance; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Ministerio de Ciencia e Innovación; Astellas Pharma; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; GlaxoSmithKline; Gedeon Richter; Shionogi; Meiji Seika Pharma; Dainippon Sumitomo Pharma; Generalitat de Catalunya; Boehringer Ingelheim Japan; Ministerstvo Školství, Mládeže a Tělovýchovy; Bundesministerium für Bildung und Forschung; Grantová Agentura České Republiky; University of New South Wales; Kyowa Hakko Kirin; Otsuka Pharmaceutical; Centro de Investigación Biomédica en Red de Salud Mental; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Wellcome Trust; Department of Biotechnology, Ministry of Science and Technology, India; Fondation FondaMental; Deutsche Forschungsgemeinschaft; H. Lundbeck A/S; Centres de Recerca de Catalunya; Sunovion; National Health and Medical Research Council; Allergan; Kanae Foundation for the Promotion of Medical Science; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Bipolar disorder; Mania; Lithium (medication); Depression (economics); Medicine; Mood disorders; Psychiatry; Suicidal ideation; Internal medicine; Cohort; Adverse effect; Family history; Schizophrenia (object-oriented programming); Mood; Poison control; Anxiety; Injury prevention","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007327351,0.0004381876,0.0002880138,0.0008109764,0.0005508413,0.0006740851,0.000327842,0.000506347,0.002026524],"category_scores_gemma":[0.001952445,0.0001635982,0.0006206666,0.001246005,0.0004011983,0.0002186532,0.0004326412,0.0004736175,0.0001607532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005039318,"about_ca_system_score_gemma":0.000348333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007126933,"about_ca_topic_score_gemma":0.008061484,"domain_scores_codex":[0.9994299,0.0002089646,0.00004794136,0.0001557384,0.00008867909,0.00006883229],"domain_scores_gemma":[0.9990596,0.0002803209,0.0004441926,0.00005714411,0.00006603789,0.00009271265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004647611,0.00004084808,0.9876594,0.00003902044,0.0003543074,0.0006574314,0.0002775694,0.0002971267,0.002535054,0.0002562411,0.0003452138,0.007072929],"study_design_scores_gemma":[0.00003355257,0.0001170273,0.9961979,0.00004098146,0.0002100173,0.0009559964,0.000168548,0.0008751203,0.0003407709,0.000613555,0.0004363829,0.00001008919],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971108,0.000741142,0.0005587521,0.0002690084,0.00001047757,0.00001564193,0.0005770319,0.0000108998,0.0007061564],"genre_scores_gemma":[0.9987643,0.0002082644,0.0004606195,0.0001021994,0.0000130163,0.00001224223,0.0003125739,0.000005812096,0.0001210782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007126933,"threshold_uncertainty_score":0.01417089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2383839635028208,"score_gpt":0.4222235280497991,"score_spread":0.1838395645469783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}